Tumour progression is modulated by the local microenvironment. This environment is
populated by many immune cells, of which macrophages are among the most abundant …

Monocytes and macrophages are critical effectors and regulators of inflammation and the
innate immune response, the immediate arm of the immune system. Dendritic cells initiate …

Macrophage-colony stimulating factor (CSF-1) signaling through its receptor (CSF-1R)
promotes the differentiation of myeloid progenitors into heterogeneous populations of …

Monocytes are circulating blood leukocytes that play important roles in the inflammatory
response, which is essential for the innate response to pathogens. But inflammation and …

We have developed a versatile Escherichia coli expression system based on the use of E.
coli thioredoxin (trxA) as a gene fusion partner. The broad utility of the system is illustrated …

The production of hematopoietic cells is under the tight control of a group of hematopoietic
cytokines. Each cytokine has multiple actions mediated by receptors whose cytoplasmic …

Recognition of an AUG initiator codon in a suboptimal context improves when a modest
amount of secondary structure is introduced near the beginning of the protein-coding …

Experiments were conducted to isolate and characterize the gene and gene product of a
human hematopoietic colony-stimulating factor with pluripotent biological activities. This …

Introduction 3. Paracrine soluble factors regulating hepatic stellate cell activation 3.1.
Transforming growth factor-beta 3.2. Tumor necrosis factor-alpha 3.3. Endothelins 3.4 …

A method for the quantitation of specific mRNA species by the polymerase chain reaction
(PCR) has been developed by using a synthetic RNA as an internal standard. The specific …