Understudied proteins: opportunities and challenges for functional proteomics
Most research aiming at understanding the molecular foundations of life and disease has
focused on a limited set of increasingly well-known proteins while the biological functions of …
focused on a limited set of increasingly well-known proteins while the biological functions of …
[HTML][HTML] Guidelines and definitions for research on epithelial–mesenchymal transition
Epithelial–mesenchymal transition (EMT) encompasses dynamic changes in cellular
organization from epithelial to mesenchymal phenotypes, which leads to functional changes …
organization from epithelial to mesenchymal phenotypes, which leads to functional changes …
[HTML][HTML] Information fusion as an integrative cross-cutting enabler to achieve robust, explainable, and trustworthy medical artificial intelligence
Medical artificial intelligence (AI) systems have been remarkably successful, even
outperforming human performance at certain tasks. There is no doubt that AI is important to …
outperforming human performance at certain tasks. There is no doubt that AI is important to …
[HTML][HTML] TGF-β Signaling
K Tzavlaki, A Moustakas - Biomolecules, 2020 - mdpi.com
Transforming growth factor-β (TGF-β) represents an evolutionarily conserved family of
secreted polypeptide factors that regulate many aspects of physiological embryogenesis …
secreted polypeptide factors that regulate many aspects of physiological embryogenesis …
Specificity, versatility, and control of TGF-β family signaling
R Derynck, EH Budi - Science signaling, 2019 - science.org
Encoded in mammalian cells by 33 genes, the transforming growth factor–β (TGF-β) family
of secreted, homodimeric and heterodimeric proteins controls the differentiation of most, if …
of secreted, homodimeric and heterodimeric proteins controls the differentiation of most, if …
Biointerface design for vertical nanoprobes
R Elnathan, MG Barbato, X Guo, A Mariano… - Nature Reviews …, 2022 - nature.com
Biointerfaces mediate safe and efficient cell manipulation, which is essential for biomedical
innovations in advanced therapies and diagnostics. The biointerface established by vertical …
innovations in advanced therapies and diagnostics. The biointerface established by vertical …
An efficient KRAB domain for CRISPRi applications in human cells
Clustered regularly interspaced short palindromic repeat interference (CRISPRi), based on
the fusion of inactive Cas9 (dCas9) to the Krüppel-associated box (KRAB) repressor, is a …
the fusion of inactive Cas9 (dCas9) to the Krüppel-associated box (KRAB) repressor, is a …
Tight junctions: from simple barriers to multifunctional molecular gates
C Zihni, C Mills, K Matter, MS Balda - Nature reviews Molecular cell …, 2016 - nature.com
Epithelia and endothelia separate different tissue compartments and protect multicellular
organisms from the outside world. This requires the formation of tight junctions, selective …
organisms from the outside world. This requires the formation of tight junctions, selective …
Non-Smad signaling pathways of the TGF-β family
YE Zhang - Cold Spring Harbor perspectives in biology, 2017 - cshperspectives.cshlp.org
Transforming growth factor β (TGF-β) and structurally related factors use several intracellular
signaling pathways in addition to Smad signaling to regulate a wide array of cellular …
signaling pathways in addition to Smad signaling to regulate a wide array of cellular …
Signaling receptors for TGF-β family members
CH Heldin, A Moustakas - Cold Spring Harbor …, 2016 - cshperspectives.cshlp.org
Transforming growth factor β (TGF-β) family members signal via heterotetrameric complexes
of type I and type II dual specificity kinase receptors. The activation and stability of the …
of type I and type II dual specificity kinase receptors. The activation and stability of the …