In late 2020, the US Food and Drug Administration (FDA) approved a lipid-based mRNA
vaccine for the prevention of COVID-19, which has pushed this field to be more closely …

Abstract mRNA formulated with lipid nanoparticles is a transformative technology that has
enabled the rapid development and administration of billions of coronavirus disease 2019 …

RNA therapeutics have the potential to resolve a myriad of genetic diseases. Lipid
nanoparticles (LNPs) are among the most successful RNA delivery systems. Expanding their …

RNA-based therapies, and siRNAs in particular, have attractive therapeutic potential for
cancer treatment due to their ability to silence genes that are imperative for tumor …

Breast cancer is the most frequently diagnosed cancer among women. Breast cancer is also
the key reason for worldwide cancer-related deaths among women. The application of small …

miRNAs are small noncoding RNAs that control gene expression at the posttranscriptional
level. It has been recognised that miRNA dysregulation reflects the state and function of cells …

Natural killer (NK) cells are cytotoxic lymphocytes that are critical for the innate immune
system. Engineering NK cells with chimeric antigen receptors (CARs) allows CAR-NK cells …

The use of biomaterials in delivering CRISPR/Cas9 for gene therapy in infectious diseases
holds tremendous potential. This innovative approach combines the advantages of …

Lipid nanoparticles (LNP) have been instrumental in the success of mRNA vaccines and
have opened up the field to a new wave of therapeutics. However, what is ahead beyond the …

RNA-based therapeutics have emerged as promising approaches to modulate gene
expression and generate therapeutic proteins or antigens capable of inducing immune …