Natural products from plants targeting key enzymes for the future development of antidiabetic agents

R Mata, L Flores-Bocanegra… - Natural Product …, 2023 - pubs.rsc.org
Covering: 2000 to January 2023 Diabetes is a metabolic disease of serious concern
nowadays, with a negative economic impact. In 2021, the International Diabetes Federation …

Silkworm pupa protein and its peptides: preparation, biological activity, applications in foods, and advantages

X Wu, J Yang, W Mumby, Y Zhang, Y Zhang… - Trends in Food Science …, 2023 - Elsevier
Background The silkworm is widely recognized as an edible insect. During its life cycle, the
silkworm goes through four developmental stages: egg, larva, pupa, and adult. Pupae, the …

[HTML][HTML] Therapeutic application of natural compounds for skeletal muscle-associated metabolic disorders: A review on diabetes perspective

K Ahmad, S Shaikh, JH Lim, SS Ahmad… - Biomedicine & …, 2023 - Elsevier
Skeletal muscle (SM) plays a vital role in energy and glucose metabolism by regulating
insulin sensitivity, glucose uptake, and blood glucose homeostasis. Impaired SM …

[HTML][HTML] The role of anti-diabetic drugs in NAFLD. Have we found the Holy Grail? A narrative review

M Zachou, P Flevari, N Nasiri-Ansari… - European Journal of …, 2024 - Springer
Purpose Non-alcoholic fatty liver disease (NAFLD) has become a leading cause of liver
disease, affecting 30% of the global population. NAFLD prevalence is particularly high in …

[HTML][HTML] Dipeptidyl peptidase-4 inhibitory potentials of Glycyrrhiza uralensis and its bioactive compounds licochalcone A and licochalcone B: An in silico and in vitro …

S Shaikh, S Ali, JH Lim, HJ Chun, K Ahmad… - Frontiers in Molecular …, 2022 - frontiersin.org
Type 2 diabetes mellitus (T2DM) is a growing global public health issue, and dipeptidyl
peptidase-4 (DPP-4) is a potential therapeutic target in T2DM. Several synthetic anti-DPP-4 …

[HTML][HTML] The combination of natural molecules naringenin, hesperetin, curcumin, polydatin and quercetin synergistically decreases SEMA3E expression levels and …

ES Scarpa, C Giordani, A Antonelli, M Petrelli… - International Journal of …, 2023 - mdpi.com
Type 2 diabetes mellitus (T2DM) is a disease characterized by a prolonged hyperglycemic
condition caused by insulin resistance mechanisms in muscle and liver, reduced insulin …

Drug discovery of plausible lead natural compounds that target the insulin signaling pathway: Bioinformatics approaches

S Shanak, N Bassalat, A Barghash… - Evidence‐Based …, 2022 - Wiley Online Library
The growing smooth talk in the field of natural compounds is due to the ancient and current
interest in herbal medicine and their potentially positive effects on health. Dozens of …

[HTML][HTML] Decoding the chemical composition and pharmacological mechanisms of Jiedu Tongluo Tiaogan Formula using high-performance liquid chromatography …

Q Zhang, C Piao, W Jin, D Jin, H Wang, C Tang… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
Type 2 diabetes mellitus (T2DM), a chronic low-grade inflammatory disease with high
morbidity and mortality, is a serious threat to public health. Previously we demonstrated that …

Therapeutic potential and action mechanisms of licochalcone B: a mini review

S Shaikh, EJ Lee, K Ahmad, I Choi - Frontiers in Molecular …, 2024 - frontiersin.org
Licochalcone B (LicB), a chalcone derived from Glycyrrhiza uralensis and Glycyrrhiza
glabra, has received considerable attention due to its diverse pharmacological properties …

Moringa oleifera Lam. as a potential plant for alleviation of the metabolic syndrome—A narrative review based on in vivo and clinical studies

S Adarthaiya, A Sehgal - Phytotherapy Research, 2024 - Wiley Online Library
The metabolic syndrome (MetS) refers to the co‐occurrence of risk factors, including
hyperglycaemia, increased body weight, hypertension and dyslipidemia, which eventually …