Clinical pancreatic islet transplantation can be considered one of the safest and least
invasive transplant procedures. Remarkable progress has occurred in both the technical …

Pancreatic islet transplantation has become an established approach to β-cell replacement
therapy for the treatment of insulin-deficient diabetes. Recent progress in techniques for islet …

Human pancreatic islets consist of multiple endocrine cell types. To facilitate the detection of
rare cellular states and uncover population heterogeneity, we performed single-cell RNA …

Background Registry data on patients with type 1 diabetes mellitus who undergo pancreatic
islet transplantation indicate that only 8 percent are free of the need for insulin therapy at …

Islet transplantation is a well-established therapeutic treatment for a subset of patients with
complicated type I diabetes mellitus. Prior to the Edmonton Protocol, only 9% of the 267 islet …

The incidence of esophageal adenocarcinoma (EAC) has increased in recent decades, and
its 5-year survival rate is less than 20%. As a well-established precursor, patients with …

Stem cell-derived β (SC-β) cells could provide unlimited human β cells toward a curative
diabetes treatment. Differentiation of SC-β cells yields transplantable islets that secrete …

Transplantation (CIT) Consortium jointly developed and implemented a harmonized process
for manufacture of the allogeneic Purified Human Pancreatic Islet (PHPI) product evaluated …

Many factors influence the outcome of islet transplantation. As islets in the early
posttransplant setting are supplied with oxygen by diffusion only and are in a hypoxic state …

The Collaborative Islet Transplant Registry (CITR) collects data on clinical islet isolations
and transplants. This retrospective report analyzed 1017 islet isolation procedures …