The ECM‐cell interaction of cartilage extracellular matrix on chondrocytes

Y Gao, S Liu, J Huang, W Guo, J Chen… - BioMed research …, 2014 - Wiley Online Library
Cartilage extracellular matrix (ECM) is composed primarily of the network type II collagen
(COLII) and an interlocking mesh of fibrous proteins and proteoglycans (PGs), hyaluronic …

Filamins in cell signaling, transcription and organ development

AX Zhou, JH Hartwig, LM Akyürek - Trends in cell biology, 2010 - cell.com
Filamins are large actin-binding proteins that stabilize delicate three-dimensional actin
filament networks and link them to cellular membranes where they integrate cell …

Genome-wide parallelism underlies contemporary adaptation in urban lizards

KM Winchell, SC Campbell-Staton… - Proceedings of the …, 2023 - National Acad Sciences
Urbanization drastically transforms landscapes, resulting in fragmentation, degradation, and
the loss of local biodiversity. Yet, urban environments also offer opportunities to observe …

Systematic analysis of somatic mutations in phosphorylation signaling predicts novel cancer drivers

J Reimand, GD Bader - Molecular systems biology, 2013 - embopress.org
Large‐scale cancer genome sequencing has uncovered thousands of gene mutations, but
distinguishing tumor driver genes from functionally neutral passenger mutations is a major …

Filamins in mechanosensing and signaling

Z Razinia, T Mäkelä, J Ylänne… - Annual review of …, 2012 - annualreviews.org
Filamins are essential, evolutionarily conserved, modular, multidomain, actin-binding
proteins that organize the actin cytoskeleton and maintain extracellular matrix connections …

[PDF][PDF] Matrix vesicles: structure, composition, formation and function in calcification

RE Wuthier, GF Lipscomb - Front Biosci, 2011 - article.imrpress.com
Introduction 3. Morphology of matrix vesicles (MVs) 3.1. Conventional transmission electron
microscopy 3.2. Cryofixation, freeze-substitution electron microscopy 3.3. Freeze-fracture …

High prevalence of growth plate gene variants in children with familial short stature treated with GH

L Plachy, V Strakova, L Elblova… - The Journal of …, 2019 - academic.oup.com
Context Familial short stature (FSS) is a term describing a growth disorder that is vertically
transmitted. Milder forms may result from the combined effect of multiple genes; more severe …

Filamin A regulates cardiovascular remodeling

S Bandaru, C Ala, AX Zhou, LM Akyürek - International journal of …, 2021 - mdpi.com
Filamin A (FLNA) is a large actin-binding cytoskeletal protein that is important for cell motility
by stabilizing actin networks and integrating them with cell membranes. Interestingly, a C …

Genetics of osteoporosis: accelerating pace in gene identification and validation

WF Li, SX Hou, B Yu, MM Li, C Férec, JM Chen - Human genetics, 2010 - Springer
Osteoporosis is characterized by low bone mineral density and structural deterioration of
bone tissue, leading to an increased risk of fractures. It is the most common metabolic bone …

Rapamycin regulates autophagy and cell adhesion in induced pluripotent stem cells

A Sotthibundhu, K McDonagh… - Stem Cell Research & …, 2016 - Springer
Background Cellular reprogramming is a stressful process, which requires cells to engulf
somatic features and produce and maintain stemness machineries. Autophagy is a process …