Outpatient randomized controlled trials to reduce COVID‐19 hospitalization: Systematic review and meta‐analysis
DJ Sullivan, D Focosi, DF Hanley… - Journal of Medical …, 2023 - Wiley Online Library
This COVID‐19 outpatient randomized controlled trials (RCTs) systematic review compares
hospitalization outcomes amongst four treatment classes over pandemic period, geography …
hospitalization outcomes amongst four treatment classes over pandemic period, geography …
COVID-19 therapeutics
Since the emergence of COVID-19 in 2020, an unprecedented range of therapeutic options
has been studied and deployed. Healthcare providers have multiple treatment approaches …
has been studied and deployed. Healthcare providers have multiple treatment approaches …
A Gaussia luciferase reporter assay for the evaluation of coronavirus Nsp5/3CLpro activity
A Vlachou, R Nchioua, K Regensburger, F Kirchhoff… - Scientific Reports, 2024 - nature.com
Human coronaviruses (hCoVs) infect millions of people every year. Among these, MERS,
SARS-CoV-1, and SARS-CoV-2 caused significant morbidity and mortality and their …
SARS-CoV-1, and SARS-CoV-2 caused significant morbidity and mortality and their …
[HTML][HTML] New Therapies and Strategies to Curb HIV Infections with a Focus on Macrophages and Reservoirs
M Marra, A Catalano, MS Sinicropi, J Ceramella… - Viruses, 2024 - mdpi.com
More than 80 million people worldwide have been infected with the human
immunodeficiency virus (HIV). There are now approximately 39 million individuals living with …
immunodeficiency virus (HIV). There are now approximately 39 million individuals living with …
Impact of some antiviral drugs on health care utilization for patients with COVID-19: a systematic review and meta-analysis
B Wei, R Zhang, H Zeng, L Wu, R He… - Expert Review of Anti …, 2023 - Taylor & Francis
Background We aimed to assess the impact of antiviral drugs (fluvoxamine, remdesivir,
lopinavir/ritonavir (LPV/r), molnupiravir, andnirmatrelvir/ritonavir (NRV/r)) on health care …
lopinavir/ritonavir (LPV/r), molnupiravir, andnirmatrelvir/ritonavir (NRV/r)) on health care …
[HTML][HTML] Outpatient regimens to reduce COVID-19 hospitalisations: a systematic review and meta-analysis of randomized controlled trials
Background During pandemics, early outpatient treatments reduce the health system
burden. Randomized controlled trials (RCTs) in COVID-19 outpatients have tested …
burden. Randomized controlled trials (RCTs) in COVID-19 outpatients have tested …
The relationship between viral clearance rates and disease progression in early symptomatic COVID-19: a systematic review and meta-regression analysis
S Singh, S Boyd, WHK Schilling… - Journal of …, 2024 - academic.oup.com
Background Effective antiviral drugs accelerate viral clearance in acute COVID-19
infections; the relationship between accelerating viral clearance and reducing severe …
infections; the relationship between accelerating viral clearance and reducing severe …
Physicochemical modeling and characterization of the adsorption mechanism of seven pharmaceutical molecules onto SARS-CoV-2 virus
O Kouira, S Bayoudh, H Smati, M Bouzid… - Materials Chemistry and …, 2023 - Elsevier
The aim of this work is to facilitate the fight against COVID-19 pandemic using a comparative
study of seven drug molecules, in order to select the most efficient drug molecules. This …
study of seven drug molecules, in order to select the most efficient drug molecules. This …
A practical guide to adopting Bayesian analyses in clinical research
LB Gunn-Sandell, EJ Bedrick, JL Hutchins… - Journal of Clinical and …, 2024 - cambridge.org
Background: Bayesian statistical approaches are extensively used in new statistical
methods but have not been adopted at the same rate in clinical and translational (C&T) …
methods but have not been adopted at the same rate in clinical and translational (C&T) …
Upstrapping to determine futility: predicting future outcomes nonparametrically from past data
Background Clinical trials often involve some form of interim monitoring to determine futility
before planned trial completion. While many options for interim monitoring exist (eg, alpha …
before planned trial completion. While many options for interim monitoring exist (eg, alpha …