Identification of a novel binding mechanism of Quinoline based molecules with lactate dehydrogenase of Plasmodium falciparum

R Singh, V Bhardwaj, R Purohit - Journal of Biomolecular Structure …, 2021 - Taylor & Francis
The deadliest disease caused by the Plasmodium species is malaria. Among other species,
the infection caused by Plasmodium falciparum (Pf) is life-threatening. The biological …

New naphtho/thienobenzo-triazoles with interconnected anti-inflammatory and cholinesterase inhibitory activity

M Mlakić, I Odak, I Faraho, S Talić, M Bosnar… - European journal of …, 2022 - Elsevier
Abstract New 1, 2, 3-triazolo (thieno) stilbenes were synthesized by Wittig reaction and
photochemically transformed to corresponding substituted thienobenzo/naphtho-triazoles in …

Synthesis of (4R)‐2‐(3‐hydroxyphenyl) thiazolidine‐4‐carboxylic acid substituted phthalocyanines: Anticancer activity on different cancer cell lines and molecular …

AT Bilgicli, H Genc Bilgicli, C Hepokur… - Applied …, 2021 - Wiley Online Library
In this study, firstly,(4R)‐2‐(3‐hydroxyphenyl) thiazolidine‐4‐carboxylic acid (1) and (4R)‐2‐
(3‐(3, 4‐dicyanophenoxy) phenyl) thiazolidine‐4‐carboxylic acid (2) were prepared. Then …

Strategies for the Construction of Benzobicyclo [3.2. 1] octane in Natural Product Synthesis

JX Liu, H Li, SP Zhang, SC Lu… - Chemistry–A European …, 2024 - Wiley Online Library
Abstract Benzobicyclo [3.2. 1] octane is a cage‐like unique motif containing a bicyclo [3.2. 1]
octane structure fused with at least one benzene ring. It is found in various natural products …

Catalytic Asymmetric Synthesis of Benzobicyclo [3.2. 1] octanes

M Anif Pasha, S Peraka… - Chemistry–A European …, 2021 - Wiley Online Library
Lawsone aldehydes were directly transformed into the biologically important, unique carbon
skeleton of chiral methanobenzo [f] azulenes/methanodibenzo [a, d][7] annulenes in high dr …

Parts‐per‐Million‐Level, Catalytic [3+ 2]‐Annulations for the Asymmetric Synthesis of Methanobenzo [7] annulenes

G Thirupathi, E Ashok, A Suresh Kumar… - … A European Journal, 2021 - Wiley Online Library
Alkyl‐lawsones selectively reacted with α‐alkyl‐nitroethylenes under 500 parts‐per‐million
(ppm) quinine‐NH‐thiourea‐catalysis to furnish the chiral methanobenzo [7] annulenes in …

Modeling and synthesis of novel oxime derivatives as potential cholinesterase inhibitors

A Ratković, K Pavlović, D Barić, Ž Marinić… - Journal of molecular …, 2020 - Elsevier
Promising test results on biological activity of our previously described benzobicyclo [3.2. 1]
octadienes, synthetically obtained by intramolecular photochemical cycloaddition reaction …

Benzobicyclo [3.2. 1] octene derivatives as a new class of cholinesterase inhibitors

T Čadež, A Grgičević, R Ahmetović, D Barić, NM Hrvat… - Molecules, 2020 - mdpi.com
A library of amine, oxime, ether, epoxy and acyl derivatives of the benzobicyclo [3.2. 1]
octene were synthesized and evaluated as inhibitors of both human acetylcholinesterase …

Tetra-substituted phthalocyanines bearing thiazolidine derivatives: synthesis, anticancer activity on different cancer cell lines, and molecular docking studies

AT Bilgiçli, C Hepokur, HG Bilgicli, B Tüzün… - Dalton …, 2021 - pubs.rsc.org
In the first step,(4R)-2-(2-hydroxyphenyl) thiazolidine-4-carboxylic acid (c) and 2-(2-(3, 4-
dicyanophenoxy) phenyl) thiazolidine-4-carboxylic acid (1) were prepared. Then, the …

A simple and easy to perform synthetic route to functionalized thienyl bicyclo [3.2. 1] octadienes

D Vuk, I Škorić, V Milašinović… - Beilstein journal of …, 2020 - beilstein-journals.org
In order to prepare novel polycyclic derivatives of bicyclo [3.2. 1] octadiene systems fused
with a thiophene ring, photochemical cyclization and aldol condensation reactions were …