γδ-T cells: an unpolished sword in human anti-infection immunity

J Zheng, Y Liu, YL Lau, W Tu - Cellular & molecular immunology, 2013 - nature.com
Abstract γδ-T cells represent a small population of immune cells, but play an indispensable
role in host defenses against exogenous pathogens, immune surveillance of endogenous …

Human Vγ9Vδ2 T cells: promising new leads for immunotherapy of infections and tumors

M Bonneville, E Scotet - Current opinion in immunology, 2006 - Elsevier
Vγ9Vδ2 T cells, a major human peripheral γδ T-cell subset, react in vitro against a wide
array of microbial agents and tumor cells. This broad reactivity pattern is conferred by non …

The role of Vδ2-negative γδ T cells during cytomegalovirus reactivation in recipients of allogeneic stem cell transplantation

A Knight, AJ Madrigal, S Grace… - Blood, The Journal …, 2010 - ashpublications.org
Reactivation of cytomegalovirus (CMV) remains a serious complication after allogeneic stem
cell transplantation, but the role of γδ T cells is undefined. We have studied the immune …

Long-term expansion of effector/memory Vδ2 γδ T cells is a specific blood signature of CMV infection

V Pitard, D Roumanes, X Lafarge… - Blood, The Journal …, 2008 - ashpublications.org
The ability of human γδ T cells to develop immunologic memory is still a matter of debate.
We previously demonstrated the involvement of Vδ2− γδ T lymphocytes in the response of …

Cutting edge: TGF-β1 and IL-15 induce FOXP3+ γδ regulatory T cells in the presence of antigen stimulation

R Casetti, C Agrati, M Wallace, A Sacchi… - The Journal of …, 2009 - journals.aai.org
Several subsets of αβ regulatory T cells (Tregs) have been described and studied
intensively, but the potential regulatory role of γδ T cells remains largely unclear …

Phosphoantigen-expanded human γδ T cells display potent cytotoxicity against monocyte-derived macrophages infected with human and avian influenza viruses

G Qin, H Mao, J Zheng, SF Sia, Y Liu… - The Journal of …, 2009 - academic.oup.com
Background Influenza virus is a cause of substantial annual morbidity and mortality
worldwide. The potential emergence of a new pandemic strain (eg, avian influenza virus) is …

Gamma delta T cells and their involvement in COVID-19 virus infections

G von Massow, S Oh, A Lam, K Gustafsson - Frontiers in immunology, 2021 - frontiersin.org
The global outbreak of the SARS-Cov-2 virus in 2020 has killed millions of people
worldwide and forced large parts of the world into lockdowns. While multiple vaccine …

The B-cell follicle in HIV infection: barrier to a cure

MP Bronnimann, PJ Skinner, E Connick - Frontiers in immunology, 2018 - frontiersin.org
The majority of HIV replication occurs in secondary lymphoid organs (SLOs) such as the
spleen, lymph nodes, and gut-associated lymphoid tissue. Within SLOs, HIV RNA+ cells are …

How to train your dragon: harnessing gamma delta T cells antiviral functions and trained immunity in a pandemic era

J Caron, LA Ridgley, M Bodman-Smith - Frontiers in immunology, 2021 - frontiersin.org
The emergence of viruses with pandemic potential such as the SARS-CoV-2 coronavirus
causing COVID-19 poses a global health challenge. There is remarkable progress in …

The aminobisphosphonate pamidronate controls influenza pathogenesis by expanding a γδ T cell population in humanized mice

W Tu, J Zheng, Y Liu, SF Sia, M Liu, G Qin… - Journal of Experimental …, 2011 - rupress.org
There are few antiviral drugs for treating influenza, and the emergence of antiviral resistance
has further limited the available therapeutic options. Furthermore, antivirals are not …