Redefining oxidative stress in Alzheimer's disease: Targeting platelet reactive oxygen species for novel therapeutic options

SK Beura, R Dhapola, AR Panigrahi, P Yadav… - Life Sciences, 2022 - Elsevier
Abstract Alzheimer's disease (AD), a progressive neurodegenerative disorder, is considered
one of the most common causes of dementia worldwide, accounting for about 80% of all …

[HTML][HTML] Beyond haemostasis and thrombosis: platelets in depression and its co-morbidities

B Izzi, A Tirozzi, C Cerletti, MB Donati… - International Journal of …, 2020 - mdpi.com
Alongside their function in primary haemostasis and thrombo-inflammation, platelets are
increasingly considered a bridge between mental, immunological and coagulation-related …

Pathophysiology and therapeutic potential of NADPH oxidases in ischemic stroke‐induced oxidative stress

J Duan, S Gao, S Tu, C Lenahan… - … Medicine and Cellular …, 2021 - Wiley Online Library
Stroke is a leading cause of death and disability in humans. The excessive production of
reactive oxygen species (ROS) is an important contributor to oxidative stress and secondary …

Antiplatelet drugs: potential therapeutic options for the management of neurodegenerative diseases

SK Beura, R Dhapola, AR Panigrahi… - Medicinal Research …, 2023 - Wiley Online Library
The blood platelet plays an important role but often remains under‐recognized in several
vascular complications and associated diseases. Surprisingly, platelet hyperactivity and …

[图书][B] NOX inhibitors: from bench to naxibs to bedside

MH Elbatreek, H Mucke, HHHW Schmidt - 2021 - Springer
Reactive oxygen species (ROS) are ubiquitous metabolic products and important cellular
signaling molecules that contribute to several biological functions. Pathophysiology arises …

[HTML][HTML] Isoform-selective NADPH oxidase inhibitor panel for pharmacological target validation

VTV Dao, MH Elbatreek, S Altenhöfer, AI Casas… - Free Radical Biology …, 2020 - Elsevier
Dysfunctional reactive oxygen species (ROS) signaling is considered an important disease
mechanism. Therapeutically, non-selective scavenging of ROS by antioxidants, however …

[HTML][HTML] Platelets, protean cells with all-around functions and multifaceted pharmacological applications

C Puricelli, E Boggio, CL Gigliotti, I Stoppa… - International Journal of …, 2023 - mdpi.com
Platelets, traditionally known for their roles in hemostasis and coagulation, are the most
prevalent blood component after erythrocytes (150,000–400,000 platelets/μL in healthy …

[HTML][HTML] Alternative platelet activation pathways and their role in neurodegenerative diseases

P Ferrer-Raventós, K Beyer - Neurobiology of Disease, 2021 - Elsevier
Purpose of the review The study of platelets in the context of neurodegenerative diseases is
intensifying, and increasing evidence suggests that platelets may play an important role in …

Modulation of integrin receptor by polyphenols: Downstream Nrf2-Keap1/ARE and associated cross-talk mediators in cardiovascular diseases

S Fakhri, SZ Moradi, Z Nouri, H Cao… - Critical Reviews in …, 2024 - Taylor & Francis
As a group of heterodimeric and transmembrane glycoproteins, integrin receptors are widely
expressed in various cell types overall the body. During cardiovascular dysfunction, integrin …

NADPH oxidases are required for full platelet activation in vitro and thrombosis in vivo but dispensable for plasma coagulation and hemostasis

D Vara, RK Mailer, A Tarafdar, N Wolska… - … , and vascular biology, 2021 - Am Heart Assoc
Objective: Using 3KO (triple NOX [NADPH oxidase] knockout) mice (ie, NOX1−/−/NOX2−/−/
NOX4−/−), we aimed to clarify the role of this family of enzymes in the regulation of platelets …