Redefining oxidative stress in Alzheimer's disease: Targeting platelet reactive oxygen species for novel therapeutic options
Abstract Alzheimer's disease (AD), a progressive neurodegenerative disorder, is considered
one of the most common causes of dementia worldwide, accounting for about 80% of all …
one of the most common causes of dementia worldwide, accounting for about 80% of all …
[HTML][HTML] Beyond haemostasis and thrombosis: platelets in depression and its co-morbidities
Alongside their function in primary haemostasis and thrombo-inflammation, platelets are
increasingly considered a bridge between mental, immunological and coagulation-related …
increasingly considered a bridge between mental, immunological and coagulation-related …
Pathophysiology and therapeutic potential of NADPH oxidases in ischemic stroke‐induced oxidative stress
Stroke is a leading cause of death and disability in humans. The excessive production of
reactive oxygen species (ROS) is an important contributor to oxidative stress and secondary …
reactive oxygen species (ROS) is an important contributor to oxidative stress and secondary …
Antiplatelet drugs: potential therapeutic options for the management of neurodegenerative diseases
SK Beura, R Dhapola, AR Panigrahi… - Medicinal Research …, 2023 - Wiley Online Library
The blood platelet plays an important role but often remains under‐recognized in several
vascular complications and associated diseases. Surprisingly, platelet hyperactivity and …
vascular complications and associated diseases. Surprisingly, platelet hyperactivity and …
[图书][B] NOX inhibitors: from bench to naxibs to bedside
MH Elbatreek, H Mucke, HHHW Schmidt - 2021 - Springer
Reactive oxygen species (ROS) are ubiquitous metabolic products and important cellular
signaling molecules that contribute to several biological functions. Pathophysiology arises …
signaling molecules that contribute to several biological functions. Pathophysiology arises …
[HTML][HTML] Isoform-selective NADPH oxidase inhibitor panel for pharmacological target validation
VTV Dao, MH Elbatreek, S Altenhöfer, AI Casas… - Free Radical Biology …, 2020 - Elsevier
Dysfunctional reactive oxygen species (ROS) signaling is considered an important disease
mechanism. Therapeutically, non-selective scavenging of ROS by antioxidants, however …
mechanism. Therapeutically, non-selective scavenging of ROS by antioxidants, however …
[HTML][HTML] Platelets, protean cells with all-around functions and multifaceted pharmacological applications
C Puricelli, E Boggio, CL Gigliotti, I Stoppa… - International Journal of …, 2023 - mdpi.com
Platelets, traditionally known for their roles in hemostasis and coagulation, are the most
prevalent blood component after erythrocytes (150,000–400,000 platelets/μL in healthy …
prevalent blood component after erythrocytes (150,000–400,000 platelets/μL in healthy …
[HTML][HTML] Alternative platelet activation pathways and their role in neurodegenerative diseases
P Ferrer-Raventós, K Beyer - Neurobiology of Disease, 2021 - Elsevier
Purpose of the review The study of platelets in the context of neurodegenerative diseases is
intensifying, and increasing evidence suggests that platelets may play an important role in …
intensifying, and increasing evidence suggests that platelets may play an important role in …
Modulation of integrin receptor by polyphenols: Downstream Nrf2-Keap1/ARE and associated cross-talk mediators in cardiovascular diseases
As a group of heterodimeric and transmembrane glycoproteins, integrin receptors are widely
expressed in various cell types overall the body. During cardiovascular dysfunction, integrin …
expressed in various cell types overall the body. During cardiovascular dysfunction, integrin …
NADPH oxidases are required for full platelet activation in vitro and thrombosis in vivo but dispensable for plasma coagulation and hemostasis
D Vara, RK Mailer, A Tarafdar, N Wolska… - … , and vascular biology, 2021 - Am Heart Assoc
Objective: Using 3KO (triple NOX [NADPH oxidase] knockout) mice (ie, NOX1−/−/NOX2−/−/
NOX4−/−), we aimed to clarify the role of this family of enzymes in the regulation of platelets …
NOX4−/−), we aimed to clarify the role of this family of enzymes in the regulation of platelets …