The carotid body (CB) is the main peripheral chemoreceptor for arterial respiratory gases O2
and CO2 and pH, eliciting reflex ventilatory, cardiovascular, and humoral responses to …

The carotid body (CB) is the main peripheral chemoreceptor that senses the arterial PO 2,
PCO 2 and pH. In response to hypoxemia, hypercapnia and acidosis, carotid chemosensory …

Despite advances in the treatment of heart failure, prognosis is poor, mortality high and there
remains no cure. Heart failure is associated with reduced cardiac pump function, autonomic …

Mammalian carotid body arterial chemoreceptors function as an early warning system for
hypoxia, triggering acute life-saving arousal and cardiorespiratory reflexes. To serve this …

Key points Heart failure with preserved ejection fraction (HFpEF) is associated with
disordered breathing patterns, and sympatho‐vagal imbalance. Although it is well accepted …

Chronic heart failure (CHF) is a major public health problem. Tonic hyper‐activation of
sympathetic neural outflow is commonly observed in patients with CHF. Importantly …

Central sleep apnea/Hunter-Cheyne-Stokes breathing (CSA/HCSB) is prevalent in patients
with heart failure with reduced ejection fraction (HFrEF). The acute pathobiologic …

Key points Peripheral chemoreflex sensitization is a feature of renovascular hypertension.
Carotid sinus nerve denervation (CSD) has recently been shown to relieve hypertension …

The treatment and management of chronic heart failure (CHF) remains an important focus
for new and more effective clinical strategies. This important goal, however, is dependent …

Human studies use varying levels of low-dose (1-4 μg· kg− 1· min− 1) dopamine to examine
peripheral chemosensitivity, based on its known ability to blunt carotid body responsiveness …