[HTML][HTML] Osteoarthritis: pathogenic signaling pathways and therapeutic targets
Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects
more than 500 million population worldwide. OA was believed to be caused by the wearing …
more than 500 million population worldwide. OA was believed to be caused by the wearing …
[PDF][PDF] Fibroblasts: Origins, definitions, and functions in health and disease
Fibroblasts are diverse mesenchymal cells that participate in tissue homeostasis and
disease by producing complex extracellular matrix and creating signaling niches through …
disease by producing complex extracellular matrix and creating signaling niches through …
Cell fate specification and differentiation in the adult mammalian intestine
Intestinal stem cells at the bottom of crypts fuel the rapid renewal of the different cell types
that constitute a multitasking tissue. The intestinal epithelium facilitates selective uptake of …
that constitute a multitasking tissue. The intestinal epithelium facilitates selective uptake of …
Large-Artery Stiffness in Health and Disease: JACC State-of-the-Art Review
A healthy aorta exerts a powerful cushioning function, which limits arterial pulsatility and
protects the microvasculature from potentially harmful fluctuations in pressure and blood …
protects the microvasculature from potentially harmful fluctuations in pressure and blood …
Undulating changes in human plasma proteome profiles across the lifespan
Aging is a predominant risk factor for several chronic diseases that limit healthspan.
Mechanisms of aging are thus increasingly recognized as potential therapeutic targets …
Mechanisms of aging are thus increasingly recognized as potential therapeutic targets …
Contextual determinants of TGFβ action in development, immunity and cancer
CJ David, J Massagué - Nature reviews Molecular cell biology, 2018 - nature.com
Few cell signals match the impact of the transforming growth factor-β (TGFβ) family in
metazoan biology. TGFβ cytokines regulate cell fate decisions during development, tissue …
metazoan biology. TGFβ cytokines regulate cell fate decisions during development, tissue …
[HTML][HTML] Bone morphogenetic protein-2 in development and bone homeostasis
D Halloran, HW Durbano, A Nohe - Journal of developmental biology, 2020 - mdpi.com
Bone morphogenetic proteins (BMPs) are multi-functional growth factors belonging to the
Transforming Growth Factor-Beta (TGF-β) superfamily. These proteins are essential to many …
Transforming Growth Factor-Beta (TGF-β) superfamily. These proteins are essential to many …
Functionalized 3D-printed silk-hydroxyapatite scaffolds for enhanced bone regeneration with innervation and vascularization
V Fitzpatrick, Z Martín-Moldes, A Deck… - Biomaterials, 2021 - Elsevier
Our goal was to generate functionalized 3D-printed scaffolds for bone regeneration using
silk-hydroxyapatite bone cements and osteoinductive, proangiogenic and neurotrophic …
silk-hydroxyapatite bone cements and osteoinductive, proangiogenic and neurotrophic …
Ferroptosis in infection, inflammation, and immunity
Ferroptosis is a type of regulated necrosis that is triggered by a combination of iron toxicity,
lipid peroxidation, and plasma membrane damage. The upstream inducers of ferroptosis …
lipid peroxidation, and plasma membrane damage. The upstream inducers of ferroptosis …
Aberrant astrocyte protein secretion contributes to altered neuronal development in multiple models of neurodevelopmental disorders
ALM Caldwell, L Sancho, J Deng, A Bosworth… - Nature …, 2022 - nature.com
Astrocytes negatively impact neuronal development in many models of neurodevelopmental
disorders (NDs); however, how they do this, and if mechanisms are shared across disorders …
disorders (NDs); however, how they do this, and if mechanisms are shared across disorders …