Antioxidant and anti‐inflammatory mechanisms of neuroprotection by ursolic acid: Addressing brain injury, cerebral ischemia, cognition deficit, anxiety, and …
S Habtemariam - Oxidative medicine and cellular longevity, 2019 - Wiley Online Library
Ursolic acid (UA) is a pentacyclic triterpene which is found in common herbs and medicinal
plants that are reputed for a variety of pharmacological effects. Both as an active principle of …
plants that are reputed for a variety of pharmacological effects. Both as an active principle of …
Ursolic acid: A systematic review of its pharmacology, toxicity and rethink on its pharmacokinetics based on PK-PD model
Q Sun, M He, M Zhang, S Zeng, L Chen, L Zhou, H Xu - Fitoterapia, 2020 - Elsevier
Ursolic acid (UA) is a natural pentacyclic triterpenoid compound existing in various
traditional Chinese medicinal herbs, and it possesses diverse pharmacological actions and …
traditional Chinese medicinal herbs, and it possesses diverse pharmacological actions and …
Advances in anti-inflammatory activity, mechanism and therapeutic application of ursolic acid
M Luan, H Wang, J Wang, X Zhang… - Mini reviews in …, 2022 - ingentaconnect.com
In vivo and in vitro studies reveal that Ursolic Acid (UA) is able to counteract endogenous
and exogenous inflammatory stimuli and has favorable anti-inflammatory effects. The …
and exogenous inflammatory stimuli and has favorable anti-inflammatory effects. The …
The calcium/calmodulin-dependent kinases II and IV as therapeutic targets in neurodegenerative and neuropsychiatric disorders
K Sałaciak, A Koszałka, E Żmudzka… - International Journal of …, 2021 - mdpi.com
CaMKII and CaMKIV are calcium/calmodulin-dependent kinases playing a rudimentary role
in many regulatory processes in the organism. These kinases attract increasing interest due …
in many regulatory processes in the organism. These kinases attract increasing interest due …
Oleanolic acid and ursolic acid: Therapeutic potential in neurodegenerative diseases, neuropsychiatric diseases and other brain disorders
C Chen, Q Ai, A Shi, N Wang, L Wang… - Nutritional …, 2023 - Taylor & Francis
Brain disorders such as neurodegenerative diseases and neuropsychiatric diseases have
become serious threatens to human health and quality of life. Oleanolic acid (OA) and …
become serious threatens to human health and quality of life. Oleanolic acid (OA) and …
Therapeutic potential of ursolic acid to manage neurodegenerative and psychiatric diseases
Ursolic acid is a pentacyclic triterpenoid found in several plants. Despite its initial use as a
pharmacologically inactive emulsifier in pharmaceutical, cosmetic and food industries …
pharmacologically inactive emulsifier in pharmaceutical, cosmetic and food industries …
Antidepressant effect of helicid in chronic unpredictable mild stress model in rats
J Tong, Z Zhou, W Qi, S Jiang, B Yang, Z Zhong… - International …, 2019 - Elsevier
Abstract Helicid (4-formylphenyl-β-D-allopyranoside) is a bioactive constituent of Helicid
nilgirica Bedd that has been used in Chinese traditional herbal medicine to treat headache …
nilgirica Bedd that has been used in Chinese traditional herbal medicine to treat headache …
The antidepressant-like effect of guanosine is dependent on GSK-3β inhibition and activation of MAPK/ERK and Nrf2/heme oxygenase-1 signaling pathways
Although guanosine is an endogenous nucleoside that displays antidepressant-like
properties in several animal models, the mechanism underlying its antidepressant-like …
properties in several animal models, the mechanism underlying its antidepressant-like …
Ursolic acid inhibits the synaptic release of glutamate and prevents glutamate excitotoxicity in rats
TK Lin, KC Yeh, MS Pai, PW Hsieh, SJ Wang - European Journal of …, 2024 - Elsevier
The present study evaluated the effect of ursolic acid, a natural pentacyclic triterpenoid, on
glutamate release in rat cortical nerve terminals (synaptosomes) and its neuroprotection in a …
glutamate release in rat cortical nerve terminals (synaptosomes) and its neuroprotection in a …
Ursolic acid ameliorates stress and reactive oxygen species in C. elegans knockout mutants by the dopamine Dop1 and Dop3 receptors
J Naß, T Efferth - Phytomedicine, 2021 - Elsevier
Background Depression and stress-related disorders are leading causes of death
worldwide. Standard treatments elevating serotonin or noradrenaline levels are not …
worldwide. Standard treatments elevating serotonin or noradrenaline levels are not …