Clinical manifestations and immune response to tuberculosis

ML Carabalí-Isajar, OH Rodríguez-Bejarano… - World Journal of …, 2023 - Springer
Tuberculosis is a far-reaching, high-impact disease. It is among the top ten causes of death
worldwide caused by a single infectious agent; 1.6 million tuberculosis-related deaths were …

Adipsin in the pathogenesis of cardiovascular diseases

A Dare, SY Chen - Vascular pharmacology, 2024 - Elsevier
Adipsin is an adipokine predominantly synthesized in adipose tissues and released into
circulation. It is also known as complement factor-D (CFD), acting as the rate-limiting factor …

Clinical Characteristics and Mechanisms of Acute Myocarditis

S Heymans, S Van Linthout, SM Kraus… - Circulation …, 2024 - ahajournals.org
Myocarditis is defined by an immune response to infection or injury, most commonly
identified after a viral infection or recent exposure to cardiotoxins or drugs. Classic …

Reward system activation improves recovery from acute myocardial infarction

H Haykin, E Avishai, M Krot, M Ghiringhelli… - Nature Cardiovascular …, 2024 - nature.com
Psychological processes have a crucial role in the recovery from acute myocardial infarction
(AMI), yet the underlying mechanisms of these effects remain elusive. Here we demonstrate …

Adipsin inhibits Irak2 mitochondrial translocation and improves fatty acid β-oxidation to alleviate diabetic cardiomyopathy

MY Jiang, WR Man, XB Zhang, XH Zhang… - Military Medical …, 2023 - Springer
Background Diabetic cardiomyopathy (DCM) causes the myocardium to rely on fatty acid β-
oxidation for energy. The accumulation of intracellular lipids and fatty acids in the …

[HTML][HTML] The SIRT3-ATAD3A axis regulates MAM dynamics and mitochondrial calcium homeostasis in cardiac hypertrophy

Z Li, O Hu, S Xu, C Lin, W Yu, D Ma, J Lu… - International Journal of …, 2024 - ncbi.nlm.nih.gov
Mitochondria are energy-producing organelles that are mobile and harbor dynamic network
structures. Although mitochondria and endoplasmic reticulum (ER) play distinct cellular …

Complement activation products in tears of dry eye and meibomian gland dysfunction

H Maehara, K Norikawa, K Tanaka, Y Kato, A Kasai… - Scientific Reports, 2024 - nature.com
Abstract Sixty-seven patients (38 woman; median age, 69 years) were enrolled to assess
complement activation products (CAPs) in tear fluid with/without dry eye (DE) and …

Revisiting the role of the complement system in intracerebral hemorrhage and therapeutic prospects

Y Li, C Tao, N An, H Liu, Z Liu, H Zhang, Y Sun… - International …, 2023 - Elsevier
Intracerebral hemorrhage (ICH) is a stroke subtype characterized by non-traumatic rupture
of blood vessels in the brain, resulting in blood pooling in the brain parenchyma. Despite its …

Role of complement factor D in cardiovascular and metabolic diseases

Y Kong, N Wang, Z Tong, D Wang, P Wang… - Frontiers in …, 2024 - frontiersin.org
In the genesis and progression of cardiovascular and metabolic diseases (CVMDs), adipose
tissue plays a pivotal and dual role. Complement factor D (CFD, also known as adipsin) …

Enrichment on steps, not genes, improves inference of differentially expressed pathways

N Markarian, KM Van Auken, D Ebert… - PLOS Computational …, 2024 - journals.plos.org
Enrichment analysis is frequently used in combination with differential expression data to
investigate potential commonalities amongst lists of genes and generate hypotheses for …