In this paper, we present a transdisciplinary framework and testable hypotheses regarding
the process of fetal programming of energy homeostasis brain circuitry. Our model proposes …

Early-life malnutrition plays a critical role in foetal development and predisposes to
metabolic diseases later in life, according to the concept of 'developmental programming' …

Many studies have found that the dysfunction in gut microbiota and the metabolic
dysfunction can promote nonalcoholic fatty liver disease (NAFLD) development. Er‐Chen …

Type 2 diabetes (T2D) has earned widespread recognition as a primary cause of death,
disability, and increasing healthcare costs. There is compelling evidence that hereditary …

Maternal nutrition during pregnancy regulates the offspring's metabolic homeostasis,
including insulin sensitivity and the metabolism of glucose and lipids. The fetus undergoes a …

A considerable number of studies have reported that maternal protein restriction may disturb
fetal growth and organ development due to a lower availability of amino acids. Leucine, one …

Purpose: The pathogenesis of metabolic associated fatty liver disease (MAFLD) is complex.
Lipid metabolic disorder, chronic inflammation, and oxidative stress are the core events for …

Background The influence of maternal diet on offspring's health is an area of study that is
linked to epigenetics. Maternal diet contributes to determining the health status of offspring …

Purpose To investigate possible mechanisms underlying the greater susceptibility of lipid
metabolism disorders in low birth weight (LBW) mice fed with high-fat diets (HFDs). Methods …

Estudos demonstram uma forte correlação entre insultos nutricionaisinadequados, como a
desnutrição proteica, durante os períodos de gestação e de lactação na gênese de doenças …