Long non-coding RNAs (lncRNAs) impact cell function via numerous mechanisms. In the
nucleus, interactions between lncRNAs and DNA and the consequent formation of non …

Multiple sequence alignment (MSA) is an important step in comparative sequence analyses.
Parallelization is a key technique for reducing the time required for large-scale sequence …

Modern protein secondary structure prediction methods are based on exploiting
evolutionary information contained in multiple sequence alignments. Critical steps in the …

I have addressed the biological rather than bioinformatics aspects of molecular sequence
alignment by covering a series of topics that have been under-valued, particularly within the …

Shotgun sequencing genomic sequences for subsequent reconstruction is comparable to
assembling a jigsaw puzzle. These puzzles, of course, are much more complex than the …

We present a profile–profile multiple alignment strategy that uses database searching to
collect homologues for each sequence in a given set, in order to enrich their available …

Homologous sequences usually have the same, or very similar, functions, so new
sequences can be reliably assigned functions if homologous sequences with known …

We introduce the online server for PRALINE (http://ibium. cs. vu. nl/programs/pralinewww/),
an iterative versatile progressive multiple sequence alignment (MSA) tool. PRALINE …

Bioinformatics programming skills are becoming a necessity across many facets of biology
and medicine, owed in part to the continuing explosion of biological data aggregation and …

Multiple sequence alignment is the NP-hard problem of aligning three or more DNA or
amino acid sequences in an optimal way so as to match as many characters as possible …