The immunosuppressive status of the tumor microenvironment (TME) remains poorly
defined due to a lack of understanding regarding the function of tumor-associated …

Macrophages are critical mediators of tissue homeostasis, with tumours distorting this
proclivity to stimulate proliferation, angiogenesis and metastasis. This had led to an interest …

Chemokines are a family of small, secreted cytokines which regulate a variety of cell
functions. The CXC motif chemokine ligand 12 (CXCL12) binds to CXC chemokine receptor …

Macrophages infiltrating tumour tissues or residing in the microenvironment of solid tumours
are known as tumour-associated macrophages (TAMs). These specialized immune cells …

The fact that various immune cells, including macrophages, can be found in tumor tissues
has long been known. With the introduction of concept that macrophages differentiate into a …

As an essential innate immune population for maintaining body homeostasis and warding
off foreign pathogens, macrophages display high plasticity and perform diverse supportive …

Established evidence demonstrates that tumor-infiltrating myeloid cells promote rather than
stop-cancer progression. Tumor-associated macrophages (TAMs) are abundantly present at …

Macrophages represent a heterogeneous cell population and are known to display a
remarkable plasticity. In response to distinct micro-environmental stimuli, eg, tumor stroma …

During atherosclerosis, the gradual accumulation of lipids into the subendothelial space of
damaged arteries results in several lipid modification processes followed by macrophage …

Type 1 diabetes is an autoimmune disorder in which the immune system attacks and
destroys insulin-producing islet cells of the pancreas. Although islet transplantation has …