Psychiatric disorders and polyphenols: can they be helpful in therapy?

J Trebatická, Z Ďuračková - Oxidative medicine and cellular …, 2015 - Wiley Online Library
The prevalence of psychiatric disorders permanently increases. Polyphenolic compounds
can be involved in modulation of mental health including brain plasticity, behaviour, mood …

[HTML][HTML] Sexual hormones regulate the redox status and mitochondrial function in the brain. Pathological implications

M Torrens-Mas, DG Pons, J Sastre-Serra, J Oliver… - Redox biology, 2020 - Elsevier
Compared to other organs, the brain is especially exposed to oxidative stress. In general,
brains from young females tend to present lower oxidative damage in comparison to their …

Drug repositioning for schizophrenia and depression/anxiety disorders: a machine learning approach leveraging expression data

K Zhao, HC So - IEEE journal of biomedical and health …, 2018 - ieeexplore.ieee.org
Development of new medications is a lengthy and costly process, and drug repositioning
might help to shorten the development cycle. We present a machine learning (ML) workflow …

Is there a glutathione centered redox dysregulation subtype of schizophrenia?

L Palaniyappan, MTM Park, P Jeon, R Limongi, K Yang… - Antioxidants, 2021 - mdpi.com
Schizophrenia continues to be an illness with poor outcome. Most mechanistic changes
occur many years before the first episode of schizophrenia; these are not reversible after the …

Alternative therapy of psychosis: Potential phytochemicals and drug targets in the management of schizophrenia

A Saleem, MF Akhtar - Frontiers in pharmacology, 2022 - frontiersin.org
Schizophrenia is a chronic mental and behavioral disorder characterized by clusters of
symptoms including hallucinations, delusions, disorganized thoughts and social withdrawal …

Genistein: a phytoestrogen with multifaceted therapeutic properties

S Saha, P Sadhukhan, PC Sil - Mini reviews in medicinal …, 2014 - ingentaconnect.com
Countless bioactive constituents obtained from different medicinal plants have long been
focused by the researchers of the scientific community and pharmaceutical industry. In …

[PDF][PDF] Computational analysis reveals the therapeutic potential of Asiatic acid against the miRNA correlated differentially expressed genes of bipolar disorder.

H Maheshwari, M Pathak, P Garg… - AIMS Molecular …, 2024 - aimspress.com
Computational analysis reveals the therapeutic potential of Asiatic acid against the miRNA
correlated differentially expressed g Page 1 AIMS Molecular Science, 11(2): 99–115. DOI …

A machine learning approach to drug repositioning based on drug expression profiles: Applications to schizophrenia and depression/anxiety disorders

K Zhao, HC So - arXiv preprint arXiv:1706.03014, 2017 - arxiv.org
Development of new medications is a very lengthy and costly process. Finding novel
indications for existing drugs, or drug repositioning, can serve as a useful strategy to shorten …

G protein-coupled estrogen receptor 1 (GPER) as a novel target for schizophrenia drug treatment

DS Macêdo, LLO Sanders… - Schizophrenia …, 2020 - academic.oup.com
The observation that a person's sex influences the onset age of schizophrenia, the course of
the disease, and antipsychotic treatment response suggests a possible role for estrogen …

Nanodelivery of Polyphenols as Nutraceuticals for CNS Disorders

PK Samaiya, R Sagar, SP Pandey… - Polyphenols: Food …, 2023 - Wiley Online Library
Central nervous system (CNS) disorders are a serious health problem worldwide. There are
a wide variety of CNS disorders, and plant‐based polyphenols have been widely explored …