Application of proteomics in cancer: recent trends and approaches for biomarkers discovery

YW Kwon, HS Jo, S Bae, Y Seo, P Song, M Song… - Frontiers in …, 2021 - frontiersin.org
Proteomics has become an important field in molecular sciences, as it provides valuable
information on the identity, expression levels, and modification of proteins. For example …

Mass spectrometry-based proteomics as an emerging tool in clinical laboratories

AG Birhanu - Clinical Proteomics, 2023 - Springer
Mass spectrometry (MS)-based proteomics have been increasingly implemented in various
disciplines of laboratory medicine to identify and quantify biomolecules in a variety of …

[HTML][HTML] Crosstalk between glioblastoma and tumor microenvironment drives proneural–mesenchymal transition through ligand-receptor interactions

Y Lai, X Lu, Y Liao, P Ouyang, H Wang, X Zhang… - Genes & …, 2024 - Elsevier
Glioblastoma (GBM) is the most common intrinsic and aggressive primary brain tumor in
adults, with a median survival of approximately 15 months. GBM heterogeneity is considered …

Proteomics separates adult-type diffuse high-grade gliomas in metabolic subgroups independent of 1p/19q codeletion and across IDH mutational status

JM Bader, N Deigendesch, M Misch, M Mann… - Cell Reports …, 2023 - cell.com
High-grade adult-type diffuse gliomas are malignant neuroepithelial tumors with poor
survival rates in combined chemoradiotherapy. The current WHO classification is based on …

[HTML][HTML] Proteomics and bioinformatics identify drug-resistant-related genes with prognostic potential in cholangiocarcinoma

K Kerdkumthong, S Roytrakul, K Songsurin… - Biomolecules, 2024 - mdpi.com
Drug resistance is a major challenge in the treatment of advanced cholangiocarcinoma
(CCA). Understanding the mechanisms of drug resistance can aid in identifying novel …

Y-box binding protein 1: Unraveling the multifaceted role in cancer development and therapeutic potential

NTM Dinh, TM Nguyen, MK Park, CH Lee - International Journal of …, 2024 - mdpi.com
Y-box binding protein 1 (YBX1), a member of the Cold Shock Domain protein family, is
overexpressed in various human cancers and is recognized as an oncogenic gene …

A five-lncRNAs signature-derived risk score based on TCGA and CGGA for glioblastoma: potential prospects for treatment evaluation and prognostic prediction

X Niu, J Sun, L Meng, T Fang, T Zhang, J Jiang… - Frontiers in …, 2020 - frontiersin.org
Accumulating studies have confirmed the crucial role of long non-coding RNAs (ncRNAs) as
favorable biomarkers for cancer diagnosis, therapy, and prognosis prediction. In our recent …

CD97 is associated with mitogenic pathway activation, metabolic reprogramming, and immune microenvironment changes in glioblastoma

MM Safaee, EJ Wang, S Jain, JS Chen, S Gill… - Scientific Reports, 2022 - nature.com
Glioblastoma (GBM) is the most common primary brain tumor with a median survival under
two years. Using in silico and in vitro techniques, we demonstrate heterogeneous …

Comparison of proteomic profiles from the testicular tissue of males with impaired and normal spermatogenesis

J Liang, Y Zheng, W Zeng, L Chen, S Yang… - Systems biology in …, 2021 - Taylor & Francis
In this study, we aimed to explore the potential differences in proteomic profiles from the
testicular tissue of azoospermatic men with impaired spermatogenesis and normal …

Biomaterial-based in vitro 3D modeling of glioblastoma multiforme

T Ahmed - Cancer Pathogenesis and Therapy, 2023 - mednexus.org
Adult-onset brain cancers, such as glioblastomas, are particularly lethal. People with
glioblastoma multiforme (GBM) do not anticipate living for more than 15 months if there is no …