Human papillomavirus E6 and E7: the cervical cancer hallmarks and targets for therapy

A Pal, R Kundu - Frontiers in microbiology, 2020 - frontiersin.org
Human papillomavirus (HPV)-induced cervical cancer is a major health issue among
women from the poorly/under-developed sectors of the world. It accounts for a high-mortality …

[HTML][HTML] Mechanistic role of HPV-associated early proteins in cervical cancer: Molecular pathways and targeted therapeutic strategies

R Bhattacharjee, SS Das, SS Biswal, A Nath… - Critical reviews in …, 2022 - Elsevier
Purpose Cervical cancer (CC), one of the major causes of death of women throughout the
world is primarily caused due to Human Papilloma Virus (HPV) 16 and 18. The early region …

Human papillomaviruses as infectious agents in gynecological cancers. Oncogenic properties of viral proteins

DA Haręża, JR Wilczyński, E Paradowska - International journal of …, 2022 - mdpi.com
Human papillomaviruses (HPVs), which belong to the Papillomaviridae family, constitute a
group of small nonenveloped double-stranded DNA viruses. HPV has a small genome that …

[HTML][HTML] The E5 proteins

D DiMaio, LM Petti - Virology, 2013 - Elsevier
The E5 proteins are short transmembrane proteins encoded by many animal and human
papillomaviruses. These proteins display transforming activity in cultured cells and animals …

MicroRNA involvement in signaling pathways during viral infection

MG Barbu, CE Condrat, DC Thompson… - Frontiers in cell and …, 2020 - frontiersin.org
The study of miRNAs started in 1993, when Lee et al. observed their involvement in the
downregulation of a crucial protein known as LIN-14 in the nematode Caenorhabditis …

The role of the PI3K/Akt/mTOR signalling pathway in human cancers induced by infection with human papillomaviruses

L Zhang, J Wu, MT Ling, L Zhao, KN Zhao - Molecular cancer, 2015 - Springer
Abstract Infection with Human papillomaviruses (HPVs) leads to the development of a wide-
range of cancers, accounting for 5% of all human cancers. A prominent example is cervical …

The role of nuclear factor-kappa B signaling in human cervical cancer

S Tilborghs, J Corthouts, Y Verhoeven, D Arias… - Critical reviews in …, 2017 - Elsevier
Abstract Background The Nuclear Factor kappaB (NF-kB) family consists of transcription
factors that play a complex and essential role in the regulation of immune responses and …

The TORrid affairs of viruses: effects of mammalian DNA viruses on the PI3K–Akt–mTOR signalling pathway

NJ Buchkovich, Y Yu, CA Zampieri… - Nature Reviews …, 2008 - nature.com
The successful replication of mammalian DNA viruses requires that they gain control of key
cellular signalling pathways that affect broad aspects of cellular macromolecular synthesis …

[HTML][HTML] Antioxidants in cervical cancer: chemopreventive and chemotherapeutic effects of polyphenols

F Di Domenico, C Foppoli, R Coccia… - Biochimica et Biophysica …, 2012 - Elsevier
Cervical cancer lesions are a major threat to the health of women, representing the second
most common cancer worldwide. The unanimously recognized etiological factor in the …

Association of p16INK4a overexpression with improved outcomes in young patients with squamous cell cancers of the oral tongue

SL Harris, LB Thorne, WT Seaman, D Neil Hayes… - Head & …, 2011 - Wiley Online Library
Background The aim of this study was to examine biomolecular profiles in a cohort of young
adults with squamous cell cancers (SCCs) of the oral tongue. Methods We identified all …