Metabolic engineering: methodologies and applications

MJ Volk, VG Tran, SI Tan, S Mishra, Z Fatma… - Chemical …, 2022 - ACS Publications
Metabolic engineering aims to improve the production of economically valuable molecules
through the genetic manipulation of microbial metabolism. While the discipline is a little over …

[HTML][HTML] Dynamic control in metabolic engineering: Theories, tools, and applications

CJ Hartline, AC Schmitz, Y Han, F Zhang - Metabolic engineering, 2021 - Elsevier
Metabolic engineering has allowed the production of a diverse number of valuable
chemicals using microbial organisms. Many biological challenges for improving bio …

Transforming yeast peroxisomes into microfactories for the efficient production of high-value isoprenoids

S Dusséaux, WT Wajn, Y Liu, C Ignea… - Proceedings of the …, 2020 - National Acad Sciences
Current approaches for the production of high-value compounds in microorganisms mostly
use the cytosol as a general reaction vessel. However, competing pathways and metabolic …

Engineering yeast for the production of plant terpenoids using synthetic biology approaches

JA Bureau, ME Oliva, Y Dong, C Ignea - Natural Product Reports, 2023 - pubs.rsc.org
Covering: 2011–2022 The low amounts of terpenoids produced in plants and the difficulty in
synthesizing these complex structures have stimulated the production of terpenoid …

Microbial production of limonene and its derivatives: Achievements and perspectives

Y Ren, S Liu, G Jin, X Yang, YJ Zhou - Biotechnology Advances, 2020 - Elsevier
Limonene and its derivatives have great market potential with diverse applications in food,
pharmaceuticals, cosmetics, etc. Commercial production of limonene and its derivatives …

Identifying and engineering the ideal microbial terpenoid production host

S Moser, H Pichler - Applied Microbiology and Biotechnology, 2019 - Springer
More than 70,000 different terpenoid structures are known so far; many of them offer highly
interesting applications as pharmaceuticals, flavors and fragrances, or biofuels. Extraction of …

Recent advances of metabolic engineering strategies in natural isoprenoid production using cell factories

M Li, F Hou, T Wu, X Jiang, F Li, H Liu, M Xian… - Natural product …, 2020 - pubs.rsc.org
Covering: up to 2019 As abundant natural products, isoprenoids have many useful industrial
applications in the manufacturing of drugs, fragrances, food additives, colorants, rubber and …

Metabolic engineering and synthetic biology for isoprenoid production in Escherichia coli and Saccharomyces cerevisiae

GR Navale, MS Dharne, SS Shinde - Applied Microbiology and …, 2021 - Springer
Isoprenoids, often called terpenoids, are the most abundant and highly diverse family of
natural organic compounds. In plants, they play a distinct role in the form of photosynthetic …

[HTML][HTML] 合成生物学重要研究方向进展

丁明珠, 李炳志, 王颖, 谢泽雄, 刘夺, 元英进 - 合成生物学, 2020 - synbioj.cip.com.cn
摘要合成生物学作为一个新兴的交叉学科领域, 随着DNA 合成技术的进步和合成生物学理念的
深入, 多个研究方向取得了长足发展. 本文主要对基因回路, 基因组设计合成 …

Orthogonal monoterpenoid biosynthesis in yeast constructed on an isomeric substrate

C Ignea, MH Raadam, MS Motawia, AM Makris… - Nature …, 2019 - nature.com
Synthetic biology efforts for the production of valuable chemicals are frequently hindered by
the structure and regulation of the native metabolic pathways of the chassis. This is …