The genetic landscape and possible therapeutics of neurofibromatosis type 2

MA Ghalavand, A Asghari, M Farhadi… - Cancer Cell …, 2023 - Springer
Abstract Neurofibromatosis type 2 (NF2) is a genetic condition marked by the development
of multiple benign tumors in the nervous system. The most common tumors associated with …

[HTML][HTML] 106th Congress of the Italian Society of Otorhinolaryngology Head and Neck Surgery Official report: Surgery of the lateral skull base: a 50-year endeavour

E Zanoletti, A Mazzoni, A Martini… - Acta …, 2019 - ncbi.nlm.nih.gov
Disregarding the widely used division of skull base into anterior and lateral, since the skull
base should be conceived as a single anatomic structure, it was to our convenience to group …

A synthetic AAV vector enables safe and efficient gene transfer to the mammalian inner ear

LD Landegger, B Pan, C Askew, SJ Wassmer… - Nature …, 2017 - nature.com
Efforts to develop gene therapies for hearing loss have been hampered by the lack of safe,
efficient, and clinically relevant delivery modalities,. Here we demonstrate the safety and …

Neuroinflammation mediates noise-induced synaptic imbalance and tinnitus in rodent models

W Wang, LS Zhang, AK Zinsmaier, G Patterson… - PLoS …, 2019 - journals.plos.org
Hearing loss is a major risk factor for tinnitus, hyperacusis, and central auditory processing
disorder. Although recent studies indicate that hearing loss causes neuroinflammation in the …

Antioxidant therapy against oxidative damage of the inner ear: Protection and preconditioning

JH Pak, Y Kim, J Yi, JW Chung - Antioxidants, 2020 - mdpi.com
Oxidative stress is an important mechanism underlying cellular damage of the inner ear,
resulting in hearing loss. In order to prevent hearing loss, several types of antioxidants have …

The inflammatory microenvironment in vestibular schwannoma

CJ Hannan, D Lewis, C O'leary… - Neuro-Oncology …, 2020 - academic.oup.com
Vestibular schwannomas are tumors arising from the vestibulocochlear nerve at the
cerebellopontine angle. Their proximity to eloquent brainstem structures means that the …

New developments in neurofibromatosis type 2 and vestibular schwannoma

Y Ren, DA Chari, S Vasilijic, DB Welling… - Neuro-Oncology …, 2021 - academic.oup.com
Abstract Neurofibromatosis type 2 (NF2) is a rare autosomal dominant disorder
characterized by the development of multiple nervous system tumors due to mutation in the …

Hearing loss and vestibular schwannoma: new insights into Schwann cells implication

T Mohamed, V Melfi, A Colciago, V Magnaghi - Cell Death & Disease, 2023 - nature.com
Hearing loss (HL) is the most common and heterogeneous disorder of the sensory system,
with a large morbidity in the worldwide population. Among cells of the acoustic nerve (VIII …

NLRP3 inflammasome activation in human vestibular schwannoma: Implications for tumor-induced hearing loss

JE Sagers, MI Sahin, IS Moon, SG Ahmed… - Hearing research, 2019 - Elsevier
Vestibular schwannoma (VS) is the fourth most common intracranial tumor, arising from
neoplastic Schwann cells of the vestibular nerve and often causing debilitating …

Tumor biomechanical stiffness by magnetic resonance elastography predicts surgical outcomes and identifies biomarkers in vestibular schwannoma and meningioma

BH Duhon, K Thompson, M Fisher, VF Kaul… - Scientific Reports, 2024 - nature.com
Variations in the biomechanical stiffness of brain tumors can not only influence the difficulty
of surgical resection but also impact postoperative outcomes. In a prospective, single …