The genetic landscape and possible therapeutics of neurofibromatosis type 2
Abstract Neurofibromatosis type 2 (NF2) is a genetic condition marked by the development
of multiple benign tumors in the nervous system. The most common tumors associated with …
of multiple benign tumors in the nervous system. The most common tumors associated with …
[HTML][HTML] 106th Congress of the Italian Society of Otorhinolaryngology Head and Neck Surgery Official report: Surgery of the lateral skull base: a 50-year endeavour
E Zanoletti, A Mazzoni, A Martini… - Acta …, 2019 - ncbi.nlm.nih.gov
Disregarding the widely used division of skull base into anterior and lateral, since the skull
base should be conceived as a single anatomic structure, it was to our convenience to group …
base should be conceived as a single anatomic structure, it was to our convenience to group …
A synthetic AAV vector enables safe and efficient gene transfer to the mammalian inner ear
LD Landegger, B Pan, C Askew, SJ Wassmer… - Nature …, 2017 - nature.com
Efforts to develop gene therapies for hearing loss have been hampered by the lack of safe,
efficient, and clinically relevant delivery modalities,. Here we demonstrate the safety and …
efficient, and clinically relevant delivery modalities,. Here we demonstrate the safety and …
Neuroinflammation mediates noise-induced synaptic imbalance and tinnitus in rodent models
W Wang, LS Zhang, AK Zinsmaier, G Patterson… - PLoS …, 2019 - journals.plos.org
Hearing loss is a major risk factor for tinnitus, hyperacusis, and central auditory processing
disorder. Although recent studies indicate that hearing loss causes neuroinflammation in the …
disorder. Although recent studies indicate that hearing loss causes neuroinflammation in the …
Antioxidant therapy against oxidative damage of the inner ear: Protection and preconditioning
JH Pak, Y Kim, J Yi, JW Chung - Antioxidants, 2020 - mdpi.com
Oxidative stress is an important mechanism underlying cellular damage of the inner ear,
resulting in hearing loss. In order to prevent hearing loss, several types of antioxidants have …
resulting in hearing loss. In order to prevent hearing loss, several types of antioxidants have …
The inflammatory microenvironment in vestibular schwannoma
Vestibular schwannomas are tumors arising from the vestibulocochlear nerve at the
cerebellopontine angle. Their proximity to eloquent brainstem structures means that the …
cerebellopontine angle. Their proximity to eloquent brainstem structures means that the …
New developments in neurofibromatosis type 2 and vestibular schwannoma
Abstract Neurofibromatosis type 2 (NF2) is a rare autosomal dominant disorder
characterized by the development of multiple nervous system tumors due to mutation in the …
characterized by the development of multiple nervous system tumors due to mutation in the …
Hearing loss and vestibular schwannoma: new insights into Schwann cells implication
T Mohamed, V Melfi, A Colciago, V Magnaghi - Cell Death & Disease, 2023 - nature.com
Hearing loss (HL) is the most common and heterogeneous disorder of the sensory system,
with a large morbidity in the worldwide population. Among cells of the acoustic nerve (VIII …
with a large morbidity in the worldwide population. Among cells of the acoustic nerve (VIII …
NLRP3 inflammasome activation in human vestibular schwannoma: Implications for tumor-induced hearing loss
Vestibular schwannoma (VS) is the fourth most common intracranial tumor, arising from
neoplastic Schwann cells of the vestibular nerve and often causing debilitating …
neoplastic Schwann cells of the vestibular nerve and often causing debilitating …
Tumor biomechanical stiffness by magnetic resonance elastography predicts surgical outcomes and identifies biomarkers in vestibular schwannoma and meningioma
BH Duhon, K Thompson, M Fisher, VF Kaul… - Scientific Reports, 2024 - nature.com
Variations in the biomechanical stiffness of brain tumors can not only influence the difficulty
of surgical resection but also impact postoperative outcomes. In a prospective, single …
of surgical resection but also impact postoperative outcomes. In a prospective, single …