Glioblastoma (GBM) is the most common primary malignant brain tumor in adults.
Regardless of ideal multidisciplinary treatment, including maximal surgical resection …

Glioblastoma (GBM) is the most common primary intracranial neoplasia, and is
characterized by its extremely poor prognosis. Despite maximum surgery, chemotherapy …

Purpose BRAF V600 mutations are frequently found in several glioma subtypes, including
pleomorphic xanthoastrocytoma (PXA) and ganglioglioma and much less commonly in …

Currently, the most widely used criteria for assessing response to therapy in high-grade
gliomas are based on two-dimensional tumor measurements on computed tomography (CT) …

Recent studies have identified a Lys 27-to-methionine (K27M) mutation at one allele of
H3F3A, one of the two genes encoding histone H3 variant H3. 3, in 60% of high-grade …

Therapy options at the time of recurrence of glioblastoma multiforme are often limited. We
investigated whether treatment with a new intratumoral thermotherapy procedure using …

Purpose A randomized, phase III, placebo-controlled, partially blinded clinical trial (REGAL
[Recentin in Glioblastoma Alone and With Lomustine]) was conducted to determine the …

Purpose We evaluated the efficacy of bevacizumab, alone and in combination with
irinotecan, in patients with recurrent glioblastoma in a phase II, multicenter, open-label …

Malignant gliomas, the most common type of primary brain tumor in adults, are associated
with disproportionate cancer-related morbidity and mortality. Recently, there have been …

Purpose To evaluate single-agent activity of bevacizumab in patients with recurrent
glioblastoma. Patients and Methods Patients with recurrent glioblastoma were treated with …