The mammalian skeletal system is densely innervated by both neural and vascular
networks. Peripheral nerves in the skeleton include sensory and sympathetic nerves. The …

Healing and regeneration of bone injuries, particularly those that are associated with large
bone defects, are a complicated process. There is growing interest in the application of …

Background: Individuals who have fibrodysplasia ossificans progressiva develop an ectopic
skeleton because of genetic dysregulation of bone morphogenetic protein (BMP) signaling …

Fat occupies a significant portion of bone cavity however its function is largely unknown.
Marrow fat expands during aging and in conditions which affect energy metabolism …

Chondrogenesis and endochondral ossification are the cartilage differentiation processes
that lead to skeletal formation and growth in the developing vertebrate as well as skeletal …

Heterotopic ossification (HO) is defined as the process by which trabecular bone forms
outside of the skeletal structure, occupying space in soft tissue where it does not normally …

Recent advances in understanding the role of bone in the systemic regulation of energy
metabolism indicate that bone marrow cells, adipocytes and osteoblasts, are involved in this …

Introduction The term heterotopic ossification refers to the aberrant forma-tion of mature,
lamellar bone in nonosseous tissue. Translated from its Greek (heteros and topos) and Latin …

Heterotopic ossification (HO), or bone formation in soft tissues, is often the result of traumatic
injury. Much evidence has linked the release of BMPs (bone morphogenetic proteins) upon …

Objective: Heterotopic ossification (HO) develops frequently after modern high-energy
penetrating war injuries. The purpose of this prospective study was to identify and …