AMPA-silent synapses in brain development and pathology
Synapses are constantly generated at a high rate in the developing, prepubescent brain.
Newly generated glutamatergic synapses lack functional AMPA receptor-mediated …
Newly generated glutamatergic synapses lack functional AMPA receptor-mediated …
Opposing effects of neuronal activity on structural plasticity
M Fauth, C Tetzlaff - Frontiers in neuroanatomy, 2016 - frontiersin.org
The connectivity of the brain is continuously adjusted to new environmental influences by
several activity-dependent adaptive processes. The most investigated adaptive mechanism …
several activity-dependent adaptive processes. The most investigated adaptive mechanism …
Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses
S Papadia, FX Soriano, F Léveillé, MA Martel… - Nature …, 2008 - nature.com
Intrinsic antioxidant defenses are important for neuronal longevity. We found that in rat
neurons, synaptic activity, acting via NMDA receptor (NMDAR) signaling, boosted …
neurons, synaptic activity, acting via NMDA receptor (NMDAR) signaling, boosted …
Regulation of CNS synapses by neuronal MHC class I
CA Goddard, DA Butts… - Proceedings of the …, 2007 - National Acad Sciences
Until recently, neurons in the healthy brain were considered immune-privileged because
they did not appear to express MHC class I (MHCI). However, MHCI mRNA was found to be …
they did not appear to express MHC class I (MHCI). However, MHCI mRNA was found to be …
Automated quantification of neuronal networks and single-cell calcium dynamics using calcium imaging
Background Recent advances in genetically engineered calcium and membrane potential
indicators provide the potential to estimate the activation dynamics of individual neurons …
indicators provide the potential to estimate the activation dynamics of individual neurons …
Genetic controls balancing excitatory and inhibitory synaptogenesis in neurodevelopmental disorder models
CL Gatto, K Broadie - Frontiers in synaptic neuroscience, 2010 - frontiersin.org
Proper brain function requires stringent balance of excitatory and inhibitory synapse
formation during neural circuit assembly. Mutation of genes that normally sculpt and …
formation during neural circuit assembly. Mutation of genes that normally sculpt and …
[HTML][HTML] The subtype of GluN2 C-terminal domain determines the response to excitotoxic insults
It is currently unclear whether the GluN2 subtype influences NMDA receptor (NMDAR)
excitotoxicity. We report that the toxicity of NMDAR-mediated Ca 2+ influx is differentially …
excitotoxicity. We report that the toxicity of NMDAR-mediated Ca 2+ influx is differentially …
β-amyloid-induced dynamin 1 degradation is mediated by N-methyl-D-aspartate receptors in hippocampal neurons
BL Kelly, A Ferreira - Journal of Biological Chemistry, 2006 - ASBMB
Alzheimer disease (AD) is a progressive, neurodegenerative disorder that leads to
debilitating cognitive deficits. Although little is known about the early functional or …
debilitating cognitive deficits. Although little is known about the early functional or …
Heroin relapse requires long-term potentiation-like plasticity mediated by NMDA2b-containing receptors
H Shen, K Moussawi, W Zhou… - Proceedings of the …, 2011 - National Acad Sciences
Persistent relapse to addictive drugs constitutes the most challenging problem in addiction
therapy, and is linked to impaired prefrontal cortex regulation of motivated behaviors …
therapy, and is linked to impaired prefrontal cortex regulation of motivated behaviors …
Multiple functions of precursor BDNF to CNS neurons: negative regulation of neurite growth, spine formation and cell survival
H Koshimizu, K Kiyosue, T Hara, S Hazama, S Suzuki… - Molecular brain, 2009 - Springer
Background Proneurotrophins and mature neurotrophins elicit opposite effects via the p75
neurotrophin receptor (p75 NTR) and Trk tyrosine kinase receptors, respectively; however …
neurotrophin receptor (p75 NTR) and Trk tyrosine kinase receptors, respectively; however …