As an evolutionarily conserved signalling network, the Hippo pathway plays a crucial role in
the regulation of numerous biological processes. Thus, substantial efforts have been made …

The Hippo pathway is an evolutionarily conserved signalling pathway with key roles in
organ development, epithelial homeostasis, tissue regeneration, wound healing and …

Neutrophils are the first line of defense against bacteria and fungi and help combat parasites
and viruses. They are necessary for mammalian life, and their failure to recover after …

TLR4 signaling plays key roles in the innate immune response to microbial infection. Innate
immune cells encounter different mechanical cues in both health and disease to adapt their …

Epstein-Barr virus (EBV) is usually acquired silently early in life and carried thereafter as an
asymptomatic infection of the B lymphoid system. However, many circumstances disturb the …

Primary immunodeficiencies (PID) are disorders that for the most part result from mutations
in genes involved in immune host defense and immunoregulation. These conditions are …

Human papillomavirus (HPV), a common sexually transmitted virus infecting mucosal or
cutaneous stratified epithelia, is implicated in the rising of associated cancers worldwide …

Transcriptional enhanced associate domain (TEAD) transcription factors play important roles
during development, cell proliferation, regeneration, and tissue homeostasis. TEAD …

Reactive oxygen species (ROS) production in phagocytes is a major defense mechanism
against pathogens. However, the cellular self-protective mechanism against such potential …

Although the fetal immune system is considered tolerogenic, preterm infants can suffer from
severe intestinal inflammation, including necrotizing enterocolitis (NEC). Here, we …