Reactive oxygen species (ROS), initially categorized as toxic by-products of aerobic
metabolism, have often been called a double-edged sword. ROS are considered …

Inflammatory bowel diseases (IBD), including colitis ulcerosa and Crohn's disease, are
chronic diseases of the gastrointestinal tract for which the cause has not been fully …

Blood-testis barrier (BTB) creates a privileged niche indispensable for spermatogenesis.
Glyphosate (GLY), the most commonly used herbicide worldwide, has been reported to …

Background: It is important to identify patients with monogenic IBD as management may
differ from classical IBD. In this position statement we formulate recommendations for the …

Inflammatory bowel disease is characterized by defects in epithelial function and
dysregulated inflammatory signaling by lamina propria mononuclear cells including …

IBD is a complex multifactorial inflammatory disease of the gut driven by extrinsic and
intrinsic factors, including host genetics, the immune system, environmental factors and the …

Reactive oxygen species (ROS) have been correlated with almost every human disease. Yet
clinical exploitation of these hypotheses by pharmacological modulation of ROS has been …

Reactive oxygen species (ROS) are highly reactive oxygen derivatives. Initially, they were
considered as metabolic by-products (of mitochondria in particular), which consistently lead …

Background & aims Monogenic forms of inflammatory bowel disease (IBD) illustrate the
essential roles of individual genes in pathways and networks safeguarding immune …

Neutrophils are phagocytic innate immune cells essential for killing bacteria via activation of
a wide variety of effector responses and generation of large amounts of reactive oxygen …