Simple Summary Cell fate is ultimately determined by the precisely coordinated action of the
Ca2+-signaling machinery. During carcinogenesis, Ca2+ signaling is significantly …

The mechanical environment is important for tumorigenesis and progression. Tumor cells
can sense mechanical signals by mechanosensitive receptors, and these mechanical …

Simple Summary The common activation of the c-Myc oncogene in colorectal cancer (CRC)
induces the overexpression of ornithine decarboxylase (ODC), the limiting step in polyamine …

A complex interplay between the extracellular space, cytoplasm and individual organelles
modulates Ca 2+ signaling to impact all aspects of cell fate and function. In recent years, the …

Emerging evidence indicates that resolution of inflammation is a critical and dynamic
endogenous process for host tissues defending against external invasive pathogens or …

Epithelial-mesenchymal transition (EMT) is a form of cellular phenotypic plasticity and is
considered a crucial step in the progression of many cancers. The calcium ion (Ca 2+) acts …

Background Breast cancer is the most commonly detected cancer and one of the leading
causes of cancer mortality. Emerging evidence supports that aberrant expression of …

Breast cancer-associated deaths are related mainly to specific molecular subtypes and the
presence of metastasis. The Epithelial-to-Mesenchymal Transition (EMT) and Ca2+ …

Significant developments in cancer treatment have been made since the advent of immune
therapies. However, there are still some patients with malignant tumors who do not benefit …