Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite
accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite …

The physiological processes of cell growth, proliferation, differentiation, and apoptosis are
closely related to STAT3, and it has been demonstrated that aberrant STAT3 expression has …

Metazoan tissue specification is associated with integration of macrophage lineage cells in
sub-tissular niches to promote tissue development and homeostasis. Oncogenic …

Macrophages are important components of the immune system. Mature macrophages can
be recruited to tumor microenvironment that affect tumor cell proliferation, invasion and …

Tumor-associated macrophages (TAMs) are critical in promoting tumor progression and
therapeutic resistance. In adapting to metabolic changes in the tumor microenvironment …

Macrophage polarization is influenced by lipids, which also exert significant control over
macrophage functions. Lipids and their metabolites are players in intricate signaling …

Immunoregulatory B cells impede antitumor immunity through unknown features and
mechanisms. We report the existence of leucine-tRNA-synthetase-2 (LARS2)-expressing B …

The immune response is tailored to the environment in which it takes place. Immune cells
sense and adapt to changes in their surroundings, and it is now appreciated that in addition …

Abstract miR-17-5p has been found to be involved in the proliferation and metastasis of
colorectal cancer (CRC), and N 6-methyladenosine (m6A) modification is the most common …

The complexity and plasticity of the tumor microenvironment (TME) make it difficult to fully
understand the intratumoral regulation of different cell types and their activities …