Abstract Introduction Recently, Nrf2/HO-1 has received extensive attention as the main
regulatory pathway of intracellular defense against oxidative stress and is considered an …

At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …

Free radicals, reactive oxygen/nitrogen species (ROS/RNS), hydrogen sulphide, and
hydrogen peroxide play an important role in both intracellular and intercellular signaling; …

Heme oxygenases (HO) catabolize free heme, that is, iron (Fe) protoporphyrin (IX), into
equimolar amounts of Fe2+, carbon monoxide (CO), and biliverdin. The stress-responsive …

Atherosclerosis is an inflammatory process of the vascular wall characterized by the
infiltration of lipids and inflammatory cells. Oxidative modifications of infiltrating low-density …

Atherosclerosis is an inflammatory disease of the wall of large-and medium-sized arteries
that is precipitated by elevated levels of low-density lipoprotein (LDL) cholesterol in the …

The heme oxygenases, which consist of constitutive and inducible isozymes (HO-1, HO-2),
catalyze the rate-limiting step in the metabolic conversion of heme to the bile pigments (ie …

Atherosclerosis remains the underlying process responsible for cardiovascular diseases
and the high mortality rates associated. This chronic inflammatory disease progresses with …

This review is intended to stimulate interest in the effect of increased expression of heme
oxygenase-1 (HO-1) protein and increased levels of HO activity on normal and pathological …

Oxidative stress plays a critical role in the pathogenesis of atherosclerosis including the
formation of lipid laden macrophages and the development of inflammation. However …