Autoimmune diseases are a diverse group of conditions characterized by aberrant B cell
and T cell reactivity to normal constituents of the host. These diseases occur widely and …

Rheumatoid arthritis (RA) is an autoimmune disease that involves multiple joints bilaterally.
It is characterized by an inflammation of the tendon (tenosynovitis) resulting in both cartilage …

Fifty years since the first description of an association between HLA and human disease,
HLA molecules have proven to be central to physiology, protective immunity and …

Multiple genetic and environmental factors have been associated with an increased risk for
rheumatoid arthritis (RA). Of these, the strongest associations have been seen with female …

In the past 50 years, variants in the major histocompatibility complex (MHC) locus, also
known as the human leukocyte antigen (HLA), have been reported as major risk factors for …

Almost two decades after the identification of SNCA as the first causative gene in
Parkinson's disease (PD) and the subsequent understanding that genetic factors play a …

Systemic lupus erythematosus (SLE) is an autoimmune disease with marked gender and
ethnic disparities. We report a large transancestral association study of SLE using …

Studies in diverse biological systems have indicated that host–parasite co-evolution is
responsible for the extraordinary genetic diversity seen in some genomic regions, such as …

The same mutation can have different effects in different individuals. One important reason
for this is that the outcome of a mutation can depend on the genetic context in which it …

Background: Evidence for a potential link between air pollution and rheumatoid arthritis (RA)
is inconsistent, and the modified effect of genetic susceptibility on the relationship between …