Aim Our aim was to update the recommendations for the diagnosis, treatment and follow‐up
of the first febrile urinary tract infection in young children, which were endorsed in 2012 by …

Antibiotic tolerance—the ability of bacteria to survive for an extended time in the presence of
bactericidal antibiotics—is an understudied contributor to antibiotic treatment failure. Herein …

Antibiotic drugs have revolutionized medicine and made our modern way of life possible. In
addition to their essential role in the clinic, antibiotics are used in a huge array of non …

The success of antimicrobial treatment is threatened by the evolution of drug resistance.
Population genetic models are an important tool in mitigating that threat. However, most …

Rationale: There is accumulating evidence that higher-than-standard doses of isoniazid are
effective against low-to-intermediate–level isoniazid-resistant strains of Mycobacterium …

Antibiotic resistance is rising and we urgently need to gain a better quantitative
understanding of how antibiotics act, which in turn would also speed up the development of …

Understanding how antibiotics inhibit bacteria can help to reduce antibiotic use and hence
avoid antimicrobial resistance—yet few theoretical models exist for bacterial growth …

Optimizing drug therapies for any disease requires a solid understanding of
pharmacokinetics (the drug concentration at a given time point in different body …

We present a mathematical model of biofilm response to antibiotics, controlled by a quorum
sensing system that confers increased resistance. The model is a highly nonlinear system of …

The terms resistance and tolerance are well defined in the context of antibiotic research.
However, in the field of disinfection, these terms are often used synonymously, which …