The endothelial cells lining the brain capillaries separate the blood from the brain
parenchyma. The endothelial monolayer of the brain capillaries serves both as a crucial …

This review considers efflux of substances from brain parenchyma quantified as values of
clearances (CL, stated in µL g− 1 min− 1). Total clearance of a substance is the sum of …

ABCG2 is an ABC transporter that extrudes a variety of compounds from cells, and presents
an obstacle in treating chemotherapy-resistant cancers. Despite recent structural insights, no …

Establishment of a human model of the blood‐brain barrier has proven to be a difficult goal.
To accomplish this, normal human brain endothelial cells were transduced by lentiviral …

In tumor cell lines, multidrug resistance is often associated with an ATP-dependent decrease
in cellular drug accumulation which is attributed to the overexpression of certain ATP …

The blood–brain barrier (BBB) is the specialized system of brain microvascular endothelial
cells (BMVEC) that shields the brain from toxic substances in the blood, supplies brain …

Long non-coding RNAs (lncRNAs) play crucial roles in the development and progression of
glioma. Previous studies indicated that lncRNA H19 regulated tumor carcinogenesis …

Brain tumors are one of the most formidable diseases of mankind. They have only a fair to
poor prognosis and high relapse rate. One of the major causes of extreme difficulty in brain …

In this review we give an overview of the physiological functions of a group of ATP binding
cassette (ABC) transporter proteins, which were discovered, and still referred to, as …

The strength of the blood-brain barrier (BBB) in providing protection to the central nervous
system from exposure to circulating chemicals is maintained by tight junctions between …