In vitro models of the blood–brain barrier: an overview of commonly used brain endothelial cell culture models and guidelines for their use
The endothelial cells lining the brain capillaries separate the blood from the brain
parenchyma. The endothelial monolayer of the brain capillaries serves both as a crucial …
parenchyma. The endothelial monolayer of the brain capillaries serves both as a crucial …
Elimination of substances from the brain parenchyma: efflux via perivascular pathways and via the blood–brain barrier
SB Hladky, MA Barrand - Fluids and Barriers of the CNS, 2018 - Springer
This review considers efflux of substances from brain parenchyma quantified as values of
clearances (CL, stated in µL g− 1 min− 1). Total clearance of a substance is the sum of …
clearances (CL, stated in µL g− 1 min− 1). Total clearance of a substance is the sum of …
ABCG2 transports anticancer drugs via a closed-to-open switch
BJ Orlando, M Liao - Nature communications, 2020 - nature.com
ABCG2 is an ABC transporter that extrudes a variety of compounds from cells, and presents
an obstacle in treating chemotherapy-resistant cancers. Despite recent structural insights, no …
an obstacle in treating chemotherapy-resistant cancers. Despite recent structural insights, no …
Blood‐brain barrier‐specific properties of a human adult brain endothelial cell line
BB Weksler, EA Subileau, N Perriere… - The FASEB …, 2005 - Wiley Online Library
Establishment of a human model of the blood‐brain barrier has proven to be a difficult goal.
To accomplish this, normal human brain endothelial cells were transduced by lentiviral …
To accomplish this, normal human brain endothelial cells were transduced by lentiviral …
Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense
In tumor cell lines, multidrug resistance is often associated with an ATP-dependent decrease
in cellular drug accumulation which is attributed to the overexpression of certain ATP …
in cellular drug accumulation which is attributed to the overexpression of certain ATP …
Blood–brain barrier: structural components and function under physiologic and pathologic conditions
Y Persidsky, SH Ramirez, J Haorah… - Journal of Neuroimmune …, 2006 - Springer
The blood–brain barrier (BBB) is the specialized system of brain microvascular endothelial
cells (BMVEC) that shields the brain from toxic substances in the blood, supplies brain …
cells (BMVEC) that shields the brain from toxic substances in the blood, supplies brain …
Long non-coding RNA H19 regulates glioma angiogenesis and the biological behavior of glioma-associated endothelial cells by inhibiting microRNA-29a
P Jia, H Cai, X Liu, J Chen, J Ma, P Wang, Y Liu… - Cancer letters, 2016 - Elsevier
Long non-coding RNAs (lncRNAs) play crucial roles in the development and progression of
glioma. Previous studies indicated that lncRNA H19 regulated tumor carcinogenesis …
glioma. Previous studies indicated that lncRNA H19 regulated tumor carcinogenesis …
Blood brain barrier: a challenge for effectual therapy of brain tumors
Brain tumors are one of the most formidable diseases of mankind. They have only a fair to
poor prognosis and high relapse rate. One of the major causes of extreme difficulty in brain …
poor prognosis and high relapse rate. One of the major causes of extreme difficulty in brain …
Human multidrug resistance ABCB and ABCG transporters: participation in a chemoimmunity defense system
In this review we give an overview of the physiological functions of a group of ATP binding
cassette (ABC) transporter proteins, which were discovered, and still referred to, as …
cassette (ABC) transporter proteins, which were discovered, and still referred to, as …
Regulation of ABC efflux transporters at blood-brain barrier in health and neurological disorders
The strength of the blood-brain barrier (BBB) in providing protection to the central nervous
system from exposure to circulating chemicals is maintained by tight junctions between …
system from exposure to circulating chemicals is maintained by tight junctions between …