The liver is a central immunological organ with a high exposure to circulating antigens and
endotoxins from the gut microbiota, particularly enriched for innate immune cells …

Resident cells of the central nervous system (CNS) play an important role in detecting insults
and initiating protective or sometimes detrimental host immunity. At peripheral sites, immune …

Chronic liver injury with any etiology can progress to fibrosis and the end-stage diseases
cirrhosis and hepatocellular carcinoma. The progression of liver disease is controlled by a …

Chronic liver injury is accompanied by a dysbalanced scarring process, termed fibrosis. This
process is mainly driven by chronic inflammation and an altered activity of a multitude of …

Cytokines are powerful mediators of inflammation. Consequently, their potency is regulated
in many ways to protect the host. Several cytokines, including IL-22, have coordinating …

Abstract Interleukin 22 (IL-22), a member of the IL-10 cytokine family and is an emerging
CD4+ Th cytokine that plays an important role in anti-microbial defense, homeostasis and …

Hepatic fibrosis is a complex mechanism defined by the net deposition of the extracellular
matrix (ECM) owing to liver injury caused by multiple etiologies such as viral hepatitis and …

湖南省在我国血吸虫病防治史上占据了特殊地位, 不但是我国血吸虫病重度流行区,
也是在我国血吸虫病防治工作不同阶段出成绩, 出经验的省份之一. 近年来 …

Fibrosis is the wound-healing response of tissues to injury. Extensive characterization of
organ fibrosis mechanisms has identified common core pathways in renal, pulmonary, skin …

T helper 22 (Th22) cells, a newly defined CD4+ T-cell lineage, are characterized by their
distinct cytokine profile, which primarily consists of IL-13, IL-22 and TNF-α. Th22 cells …