Reactive oxygen species (ROS) and mitochondria play a pivotal role in regulating platelet
functions. Platelet activation determines a drastic change in redox balance and in platelet …

Nitric oxide synthases (NOS) are a family of isoforms responsible for the synthesis of the
potent dilator nitric oxide (NO). Expression of inducible NOS (iNOS) occurs in conditions of …

Reactive oxygen species (ROS) are generated within activated platelets and play an
important role in regulating platelet responses to collagen and collagen-mediated thrombus …

Platelets are small anucleate cells generated from megakaryocytes in the bone marrow.
Although platelet generation, maturation, and clearance are still not fully understood …

Oxidative stress (OS) is a chemical imbalance between an oxidant and an antioxidant,
causing damage to redox signaling and control or causing molecular damage. Unbalanced …

Reactive oxygen species (ROS) have physiological roles as second messengers, but can
also exert detrimental modifications on DNA, proteins and lipids if resulting from enhanced …

Background The release of neutrophil extracellular traps (NETs), a mesh of DNA, histones
and neutrophil proteases from neutrophils, was first demonstrated as a host defence against …

Alongside their function in primary haemostasis and thrombo-inflammation, platelets are
increasingly considered a bridge between mental, immunological and coagulation-related …

The phagocytic cell enzyme NADPH oxidase-2 (Nox2) is critical for killing micro-organisms
via production of reactive oxygen species and thus is a key element of the innate immune …

Objective—Reactive oxygen species (ROS) are known to regulate platelet activation;
however, the mechanisms of ROS production during platelet activation remain unclear …