Recent investigations have demonstrated that neurons have a number of different types of
calcium channels, each with their own unique properties and pharmacology. These calcium …

The L-type calcium channels (LTCCs) Ca v 1.2 and Ca v 1.3, encoded by the CACNA1C
and CACNA1D genes, respectively, are important regulators of calcium influx into cells and …

This review describes interactions between compounds, primarily dihydropyridines, that
block L-type calcium channels and drugs that cause dependence, and the potential …

The major pharmacological findings with nimodipine reviewed in this chapter are
summarized in TABLE 3. On the basis of these findings, the following conclusions appear to …

Drug addiction represents a major social problem where addicts and alcoholics continue to
seek and take drugs despite adverse social, personal, emotional, and legal consequences …

Opioid addiction has reached the epidemic status in the United States in recent years. A
multitude of factors have contributed to an alarming increase in misuse and health issues …

Regulation of L-type Ca 2+ channels by morphine in rat brain was determined by the
binding of [3 H] nimodipine. Morphine, administered by subcutaneous pellet implantation …

The μ-opioid [d-Ala2, N-Me-Phe4, Gly-ol5]-enkephalin (DAMGO) exerts a peripheral
antinociceptive effect against prostaglandin E2 (PGE2)-induced mechanical hyperalgesia in …

This pilot study examined the efficacy of the N-type calcium channel blocker gabapentin to
improve outcomes during a brief detoxification protocol with buprenorphine. Treatment …

The aim of the present study has been to characterize the regulation by opiates of 45 Ca 2+
influx in rat spinal cord-dorsal root ganglion cocultures. We have demonstrated that …