From monocytes to M1/M2 macrophages: phenotypical vs. functional differentiation

P Italiani, D Boraschi - Frontiers in immunology, 2014 - frontiersin.org
Studies on monocyte and macrophage biology and differentiation have revealed the
pleiotropic activities of these cells. Macrophages are tissue sentinels that maintain tissue …

Molecular and cellular pathways contributing to joint damage in rheumatoid arthritis

Q Fang, C Zhou, KS Nandakumar - Mediators of inflammation, 2020 - Wiley Online Library
Rheumatoid arthritis is a chronic autoimmune syndrome associated with several genetic,
epigenetic, and environmental factors affecting the articular joints contributing to cartilage …

Role of osteopontin in bone remodeling and orthodontic tooth movement: a review

A Singh, G Gill, H Kaur, M Amhmed, H Jakhu - Progress in orthodontics, 2018 - Springer
In this review, most of the known and postulated mechanisms of osteopontin (OPN) and its
role in bone remodeling and orthodontic tooth movement are discussed based on available …

The role of cytokines in inflammatory bone loss

PPC Souza, UH Lerner - Immunological investigations, 2013 - Taylor & Francis
Chronic inflammatory processes close to bone often lead to loss of bone in diseases such as
rheumatoid arthritis, periodontitis, loosened joint prosthesis and tooth implants. This is …

The roles of bone‐derived exosomes and exosomal micro RNA s in regulating bone remodelling

Y Xie, Y Chen, L Zhang, W Ge… - Journal of cellular and …, 2017 - Wiley Online Library
Pathological destructive bone diseases are primarily caused by the failure of a lifelong self‐
renewal process of the skeletal system called bone remodelling. The mechanisms …

[HTML][HTML] Hematopoietic versus leukemic stem cell quiescence: Challenges and therapeutic opportunities

E O'Reilly, HA Zeinabad, E Szegezdi - Blood Reviews, 2021 - Elsevier
Hematopoietic stem cells (HSC) are responsible for the production of mature blood cells. To
ensure that the HSC pool does not get exhausted over the lifetime of an individual, most …

CircFam190a: a critical positive regulator of osteoclast differentiation via enhancement of the AKT1/HSP90β complex

K Chen, X Chen, C Lang, X Yuan, J Huang… - … & Molecular Medicine, 2023 - nature.com
The identification of key regulatory factors that control osteoclastogenesis is important.
Accumulating evidence indicates that circular RNAs (circRNAs) are discrete functional …

Importance and regulation of adult stem cell migration

B de Lucas, LM Pérez… - Journal of cellular and …, 2018 - Wiley Online Library
Cell migration is an essential process throughout the life of vertebrates, beginning during
embryonic development and continuing throughout adulthood. Stem cells have an inherent …

Lysosomes in cancer—living on the edge (of the cell)

S Hämälistö, M Jäättelä - Current opinion in cell biology, 2016 - Elsevier
The lysosomes have definitely polished their status inside the cell. Being discovered as the
last resort of discarded cellular biomass, the steady rising of this versatile signaling …

Molecular mechanisms of obesity-induced osteoporosis and muscle atrophy

B Roy, ME Curtis, LS Fears, SN Nahashon… - Frontiers in …, 2016 - frontiersin.org
Obesity and osteoporosis are two alarming health disorders prominent among middle and
old age populations, and the numbers of those affected by these two disorders are …