The lungs are exposed to reactive oxygen species oxygen (ROS) produced as a result of
inhalation of oxygen, as well as smoke and other air pollutants. Cell metabolism and the …

Inflammation of the human lung is mediated in response to different stimuli (eg, physical,
radioactive, infective, pro-allergenic or toxic) such as cigarette smoke and environmental …

The lung is a delicate organ with a large surface area that is continuously exposed to the
external environment, and is therefore highly vulnerable to exogenous sources of oxidative …

In the cardiomyocyte, CaMKII has been identified as a nodal influencer of excitation–
contraction and also excitation–transcription coupling. Its activity can be regulated in …

The cardiac field has benefited from the availability of several CaMKII inhibitors serving as
research tools to test putative CaMKII pathways associated with cardiovascular physiology …

Allergic asthma has a global prevalence, morbidity, and mortality. Many environmental
factors, such as pollutants and allergens, are highly relevant to allergic asthma. The most …

Environmental pollutants and allergens induce oxidative stress and mitochondrial
dysfunction, leading to key features of allergic asthma. Dysregulations in autophagy …

Ventricular arrhythmia is the leading cause of sudden cardiac death (SCD). Deranged
cardiac metabolism and abnormal redox state during cardiac diseases foment …

Although it has been known for decades that hippocampal calcium/calmodulin (CaM)-
dependent protein kinase II (CaMKII) plays an essential role in learning and memory …

Calcium and redox signaling both play important roles in the pathogenesis of cardiac
disease; although how these signals are integrated in the heart remains unclear. One …