A model for RAS mutation patterns in cancers: finding the sweet spot
S Li, A Balmain, CM Counter - Nature Reviews Cancer, 2018 - nature.com
The three RAS genes—HRAS, NRAS and KRAS—are collectively mutated in one-third of
human cancers, where they act as prototypic oncogenes. Interestingly, there are rather …
human cancers, where they act as prototypic oncogenes. Interestingly, there are rather …
Ubiquitination in disease pathogenesis and treatment
D Popovic, D Vucic, I Dikic - Nature medicine, 2014 - nature.com
Ubiquitination is crucial for a plethora of physiological processes, including cell survival and
differentiation and innate and adaptive immunity. In recent years, considerable progress has …
differentiation and innate and adaptive immunity. In recent years, considerable progress has …
Interaction between Wnt/β-catenin and RAS-ERK pathways and an anti-cancer strategy via degradations of β-catenin and RAS by targeting the Wnt/β-catenin pathway
Aberrant activation of the Wnt/β-catenin and RAS-extracellular signal-regulated kinase
(ERK) pathways play important roles in the tumorigenesis of many different types of cancer …
(ERK) pathways play important roles in the tumorigenesis of many different types of cancer …
Wnt5a induces and maintains prostate cancer cells dormancy in bone
In a substantial fraction of prostate cancer (PCa) patients, bone metastasis appears after
years or even decades of latency. Canonical Wnt/β-catenin signaling has been proposed to …
years or even decades of latency. Canonical Wnt/β-catenin signaling has been proposed to …
[HTML][HTML] The functions and regulation of Smurfs in cancers
L Fu, CP Cui, X Zhang, L Zhang - Seminars in cancer biology, 2020 - Elsevier
Smad ubiquitination regulatory factor 1 (Smurf1) and Smurf2 are HECT-type E3 ubiquitin
ligases, and both Smurfs were initially identified to regulate Smad protein stability in the TGF …
ligases, and both Smurfs were initially identified to regulate Smad protein stability in the TGF …
Post-translational modification of RAS proteins
SL Campbell, MR Philips - Current opinion in structural biology, 2021 - Elsevier
Mutations of RAS genes drive cancer more frequently than any other oncogene. RAS
proteins integrate signals from a wide array of receptors and initiate downstream signaling …
proteins integrate signals from a wide array of receptors and initiate downstream signaling …
Ras stabilization through aberrant activation of Wnt/β-catenin signaling promotes intestinal tumorigenesis
Although the guanosine triphosphate/guanosine diphosphate loading switch is a major
regulatory mechanism that controls the activity of the guanosine triphosphatase Ras, we …
regulatory mechanism that controls the activity of the guanosine triphosphatase Ras, we …
Smurfs in protein homeostasis, signaling, and cancer
Protein ubiquitination is an evolutionary conserved highly-orchestrated enzymatic cascade
essential for normal cellular functions and homeostasis maintenance. This pathway relies on …
essential for normal cellular functions and homeostasis maintenance. This pathway relies on …
Ubiquitination of K-Ras enhances activation and facilitates binding to select downstream effectors
The guanosine triphosphate (GTP)–loaded form of the guanosine triphosphatase (GTPase)
Ras initiates multiple signaling pathways by binding to various effectors, such as the kinase …
Ras initiates multiple signaling pathways by binding to various effectors, such as the kinase …
When ubiquitination meets phosphorylation: a systems biology perspective of EGFR/MAPK signalling
Ubiquitination, the covalent attachment of ubiquitin to target proteins, has emerged as a
ubiquitous post-translational modification (PTM) whose function extends far beyond its …
ubiquitous post-translational modification (PTM) whose function extends far beyond its …