Experimental models of Alzheimer's disease (AD) are critical to gaining a better
understanding of pathogenesis and to assess the potential of novel therapeutic approaches …

Humans have evolved much longer lifespans than the great apes, which rarely exceed 50
years. Since 1800, lifespans have doubled again, largely due to improvements in …

Alzheimer's disease (AD) is one of the looming health crises of the near future. Increasing
lifespans and better medical treatment for other conditions mean that the prevalence of this …

Executive function (EF) is a complex construct that reflects multiple higher-order cognitive
processes such as planning, updating, inhibiting and set-shifting. Decline in these functions …

There has been, and continues to be, a dramatic shift in the human population towards older
ages necessitating biomedical research aimed at better understanding the basic biology of …

Over 5 million Americans and 50 million individuals worldwide are living with Alzheimer's
disease (AD). The progressive dementia associated with AD currently has no cure. Although …

Nonhuman primates are useful for the study of age-associated changes in the brain and
behavior in a model that is biologically proximal to humans. The Aβ and tau proteins, two …

The use of non-human primate models is required to understand the ageing process and
evaluate new therapies against age-associated pathologies. The present article summarizes …

Effects of an 18-month treatment with a moderate, chronic caloric restriction (CR) or an oral
supplementation with resveratrol (RSV), a potential CR mimetic, on cognitive and motor …

Alzheimer's disease is characterized by cognitive alterations, cerebral atrophy and
neuropathological lesions including neuronal loss, accumulation of misfolded and …