Mycobacterium tuberculosis, the leading cause of death due to infection, has a dynamic and
immunomodulatory cell envelope. The cell envelope structurally and functionally varies …

The Mycobacterium tuberculosis complex (MTBC) consists of closely related species that
cause tuberculosis in both humans and animals. This illness, still today, remains to be one of …

Metabolism was once relegated to the supply of energy and biosynthetic precursors, but it
has now become clear that it is a specific mediator of nearly all physiological processes. In …

We have taken the first steps towards a complete reconstruction of the Mycobacterium
tuberculosis regulatory network based on ChIP-Seq and combined this reconstruction with …

Although phthiocerol dimycocerosates (DIM) are major virulence factors of Mycobacterium
tuberculosis (Mtb), the causative agent of human tuberculosis, little is known about their …

Bacterial capsules have evolved to be at the forefront of the cell envelope, making them an
essential element of bacterial biology. Efforts to understand the Mycobacterium tuberculosis …

Mycobacterium tuberculosis (Mtb) lipids are indelibly imprinted in just about every key
aspect of tuberculosis (TB) basic and translational research. Although the interest in these …

The cell wall of Mycobacterium tuberculosis is composed of unique lipids that are important
for pathogenesis. Indeed, the first-ever genetic screen in M. tuberculosis identified genes …

Tuberculosis is a distinctive disease in which the causative agent, Mycobacterium
tuberculosis, can persist in humans for decades by avoiding clearance from host immunity …

The genome sequence of Mycobacterium tuberculosis revealed the presence of 12
membrane proteins proposed to have a function in the transport of lipids. Insertional …