The costimulation of immune cells using first-generation anti-4-1BB monoclonal antibodies
(mAbs) has demonstrated anti-tumor activity in human trials. Further clinical development …

The incretin receptors, glucagon-like peptide-1 receptor (GLP-1R) and glucose-dependent
insulinotropic polypeptide receptor (GIPR), are prime therapeutic targets for the treatment of …

Despite more than 20 years of work since the lipid raft concept was proposed, the existence
of these nanostructures remains highly controversial due to the lack of noninvasive methods …

Background and Purpose Amino acid substitutions at the N‐termini of glucagon‐like peptide‐
1 (GLP‐1) receptor agonist peptides result in distinct patterns of intracellular signalling, sub …

The cytokine interferon‐gamma (IFN‐γ) is a master regulator of innate and adaptive
immunity involved in a broad array of human diseases that range from atherosclerosis to …

Lipid liquid–liquid immiscibility and its consequent lateral heterogeneity have been
observed under thermodynamic equilibrium in model and native membranes. However …

Fluorescent proteins are standard tools for addressing biological questions in a cell biology
laboratory. The genetic tagging of protein of interest with fluorescent proteins opens the …

The cellular plasma membrane, a seemingly chaotic structure composed of thousands of
lipids and proteins, empowers cellular life and represents a versatile hub for signalling …

G protein-coupled receptors (GPCRs) are integral membrane proteins which closely interact
with their plasma membrane lipid microenvironment. Cholesterol is a plasma membrane …

The incretin receptors, glucagon-like peptide-1 receptor (GLP-1R) and glucose-dependent
insulinotropic polypeptide receptor (GIPR), are class B GPCRs and prime therapeutic targets …