The heat shock proteins (HSPs) are ubiquitous and conserved protein families in both
prokaryotic and eukaryotic organisms, and they maintain cellular proteostasis and protect …

Mass-spectrometry-based proteomic analysis is a powerful approach for discovering new
disease biomarkers. However, certain critical steps of study design such as cohort selection …

Clinical analysis of blood is the most widespread diagnostic procedure in medicine, and
blood biomarkers are used to categorize patients and to support treatment decisions …

Extracellular vesicles (EVs) are currently of tremendous interest in many research
disciplines and EVs have potential for development of EV diagnostics or therapeutics. Most …

Next-generation sequencing allows the analysis of genomes, including those representing
disease states. However, the causes of most disorders are multifactorial, and systems-level …

Plasma and serum are rich sources of information regarding an individual's health state, and
protein tests inform medical decision making. Despite major investments, few new …

Heat shock proteins (HSPs) are an evolutionary family of proteins that act as molecular
chaperones. According to their size they have been classified into the following families; …

IgA nephropathy (IgAN) is the most common primary glomerulonephritis, frequently leading
to end-stage renal disease, as there is no disease-specific therapy. IgAN is diagnosed from …

Biomarkers are becoming increasingly important in the clinical management of complex
diseases, yet our ability to discover new biomarkers remains limited by our dependence on …

Background Biomarker identification is one of the major and important goal of functional
genomics and translational medicine studies. Large scale–omics data are increasingly …