Major depressive disorder (MDD) is a chronic, generally episodic and debilitating disease
that affects an estimated 300 million people worldwide, but its pathogenesis is poorly …

Depression is the most prevalent and debilitating mental disorder that affects a substantial
number of people globally, hindering all aspects of their lives and leading to a high number …

Stress is an essential adaptive response that enables the organism to cope with challenges
and restore homeostasis. Different stressors require distinctive corrective responses in …

Neuroinflammation is tightly associated with onset of depression. The nuclear receptor
related 1 protein (Nurr1, also called Nr4a2), its roles in dopaminergic neurons is well …

Exposure to early life stress (ELS) increases the risk for developing psychopathology;
however, the mechanisms underlying this association are not clear. In this study we …

Traumatic brain injury (TBI) is associated with significant cognitive and psychiatric
conditions. Neuropsychiatric symptoms can persist for years following brain injury, causing …

Neuronal cells are specialists for rapid transfer and translation of information. Their electrical
properties relay on a precise regulation of ion levels while their communication via …

Abstract Ethnopharmacological relevance Baihe Dihuang Decoction is a well-known
traditional Chinese medicine prescription (Also known as Lilium Henryi Baker and …

Rationale and Objectives Pro-inflammatory processes have been argued to play a role in
conditions associated with cognitive decline and neurodegeneration, like aging and obesity …

Adolescent depression is characterized by heightened inflammation and altered connectivity
of fronto-cingulate-limbic tracts, including the genu of the corpus callosum (CCG) and the …