Dying mammalian cells emit numerous signals that interact with the host to dictate the
immunological correlates of cellular stress and death. In the absence of reactive antigenic …

The regulated disruption of the plasma membrane, which can promote cell death, cytokine
secretion or both is central to organismal health. The protein gasdermin D (GSDMD) is a key …

The innate immune system detects pathogens via germline-encoded receptors that bind to
conserved pathogen ligands called pathogen-associated molecular patterns (PAMPs). Here …

Cytotoxic lymphocyte-derived granzyme A (GZMA) cleaves GSDMB, a gasdermin-family
pore-forming protein,, to trigger target cell pyroptosis. GSDMB and the charter gasdermin …

Apoptosis, necroptosis, and pyroptosis are genetically programmed cell death mechanisms
that eliminate obsolete, damaged, infected, and self-reactive cells. Apoptosis fragments cells …

Cell death supports morphogenesis during development and homeostasis after birth by
removing damaged or obsolete cells. It also curtails the spread of pathogens by eliminating …

Diseases associated with chronic inflammation constitute a major health burden across the
world. As central instigators of the inflammatory response to infection and tissue damage …

Inflammation observed in SARS-CoV-2-infected patients suggests that inflammasomes,
proinflammatory intracellular complexes, regulate various steps of infection. Lung epithelial …

The inflammasome-mediated cleavage of gasdermin D (GSDMD) causes pyroptosis and
inflammatory cytokine release to control pathogen infection, but how pathogens evade this …

Gasdermins (GSDMs) are pore-forming proteins that play critical roles in host defence
through pyroptosis,. Among GSDMs, GSDMB is unique owing to its distinct lipid-binding …