[HTML][HTML] BRCA mutations and gastrointestinal cancers: When to expect the unexpected?
E Maccaroni, R Giampieri, E Lenci… - World journal of …, 2021 - ncbi.nlm.nih.gov
BRCA1/2 pathogenic variants are widely known as major risk factors mainly for breast and
ovarian cancer, while their role in gastrointestinal (GI) malignancies such as colorectal …
ovarian cancer, while their role in gastrointestinal (GI) malignancies such as colorectal …
Evaluation of DNA double-strand break repair capacity in human cells: Critical overview of current functional methods
X Tatin, G Muggiolu, S Sauvaigo, J Breton - Mutation Research/Reviews in …, 2021 - Elsevier
DNA double-strand breaks (DSBs) are highly deleterious lesions, responsible for
mutagenesis, chromosomal translocation or cell death. DSB repair (DSBR) is therefore a …
mutagenesis, chromosomal translocation or cell death. DSB repair (DSBR) is therefore a …
Therapeutic opportunities for PLK1 inhibitors: Spotlight on BRCA1-deficiency and triple negative breast cancers
Abstract Polo-Like Kinases (PLKs) are central players of mitotic progression in Eukaryotes.
Given the intimate relationship between cell cycle progression and cancer development …
Given the intimate relationship between cell cycle progression and cancer development …
Fanconi anemia pathway in colorectal cancer: A novel opportunity for diagnosis, prognosis and therapy
Colorectal cancer (CRC) is the third most commonly diagnosed malignancy and has the
second highest mortality rate globally. Thanks to the advent of next-generation sequencing …
second highest mortality rate globally. Thanks to the advent of next-generation sequencing …
The Influence of PARP, ATR, CHK1 Inhibitors on Premature Mitotic Entry and Genomic Instability in High-Grade Serous BRCAMUT and BRCAWT Ovarian Cancer …
P Gralewska, A Gajek, D Rybaczek, A Marczak… - Cells, 2022 - mdpi.com
Olaparib is a poly (ADP-ribose) polymerase inhibitor (PARPi) that inhibits PARP1/2, leading
to replication-induced DNA damage that requires homologous recombination repair …
to replication-induced DNA damage that requires homologous recombination repair …
RAD51 separation of function mutation disables replication fork maintenance but preserves DSB repair
Homologous recombination (HR) protects replication forks (RFs) and repairs DNA double-
strand breaks (DSBs). Within HR, BRCA2 regulates RAD51 via two interaction regions: the …
strand breaks (DSBs). Within HR, BRCA2 regulates RAD51 via two interaction regions: the …
Systemic DNA Damage and Repair Activity Vary by Race in Breast Cancer Survivors
S Divekar, R Kritzer, H Shu, K Thakkar, J Hicks… - Cancers, 2024 - mdpi.com
Simple Summary Non-Hispanic Black breast cancer survivors have poorer outcomes than
White survivors, but the biological mechanisms underlying these disparities are unclear. We …
White survivors, but the biological mechanisms underlying these disparities are unclear. We …
Unscheduled MRE11 activity triggers cell death but not chromosome instability in polymerase eta-depleted cells subjected to UV irradiation
MB Federico, SO Siri, NL Calzetta, NS Paviolo… - Oncogene, 2020 - nature.com
The elimination of DNA polymerase eta (pol η) causes discontinuous DNA elongation and
fork stalling in UV-irradiated cells. Such alterations in DNA replication are followed by S …
fork stalling in UV-irradiated cells. Such alterations in DNA replication are followed by S …
The AMPK-TORC1 signalling axis regulates caffeine-mediated DNA damage checkpoint override and cell cycle effects in fission yeast
Caffeine, a widely consumed neuroactive compound, induces DNA damage checkpoint
signalling override, and enhances sensitivity to DNA damaging agents. However, the …
signalling override, and enhances sensitivity to DNA damaging agents. However, the …