T cell responses to SARS-CoV-2

A Sette, J Sidney, S Crotty - Annual review of immunology, 2023 - annualreviews.org
A large body of evidence generated in the last two and a half years addresses the roles of T
cells in SARS-CoV-2 infection and following vaccination. Infection or vaccination induces …

Prior vaccination promotes early activation of memory T cells and enhances immune responses during SARS-CoV-2 breakthrough infection

MM Painter, TS Johnston, KA Lundgreen… - Nature …, 2023 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection of vaccinated
individuals is increasingly common but rarely results in severe disease, likely due to the …

Persistent symptoms after COVID-19 are not associated with differential SARS-CoV-2 antibody or T cell immunity

DM Altmann, CJ Reynolds, G Joy, AD Otter… - Nature …, 2023 - nature.com
Among the unknowns in decoding the pathogenesis of SARS-CoV-2 persistent symptoms in
Long Covid is whether there is a contributory role of abnormal immunity during acute …

Immune responses in Omicron SARS-CoV-2 breakthrough infection in vaccinated adults

H Kared, AS Wolf, A Alirezaylavasani… - Nature …, 2022 - nature.com
Abstract The SARS-CoV-2 Omicron variant has more than 15 mutations in the receptor
binding domain of the Spike protein enabling increased transmissibility and viral escape …

Bioinformatic and experimental analysis of T cell immune reactivity to SARS-CoV-2 and its variants

A Tarke, A Grifoni, A Sette - Frontiers in Bioinformatics, 2022 - frontiersin.org
Definition of the T cells responses to SARS-CoV-2 and associated variants is critical to
understanding the complexity of adaptive immunity against SARS-CoV-2 infection. Several …

Nucleocapsid-specific T cell responses associate with control of SARS-CoV-2 in the upper airways before seroconversion

TM Eser, O Baranov, M Huth, MIM Ahmed… - Nature …, 2023 - nature.com
Despite intensive research since the emergence of SARS-CoV-2, it has remained unclear
precisely which components of the early immune response protect against the development …

[HTML][HTML] Immunological memory to common cold coronaviruses assessed longitudinally over a three-year period pre-COVID19 pandemic

ED Yu, TM Narowski, E Wang, E Garrigan, J Mateus… - Cell host & …, 2022 - cell.com
The immune memory to common cold coronaviruses (CCCs) influences SARS-CoV-2
infection outcome, and understanding its effect is crucial for pan-coronavirus vaccine …

[HTML][HTML] Accuracy of QuantiFERON SARS-CoV-2 research use only assay and characterization of the CD4+ and CD8+ T cell-SARS-CoV-2 response: comparison with …

A Aiello, A Coppola, V Vanini, L Petrone… - International Journal of …, 2022 - Elsevier
Objectives: In this study, we aimed to characterize the SARS-CoV-2-specific T cell response
detected by the QuantiFERON SARS-CoV-2 research use only assay in terms of accuracy …

SARS-CoV-2 infection establishes a stable and age-independent CD8+ T cell response against a dominant nucleocapsid epitope using restricted T cell receptors

C Choy, J Chen, J Li, DT Gallagher, J Lu, D Wu… - Nature …, 2023 - nature.com
The resolution of SARS-CoV-2 replication hinges on cell-mediated immunity, wherein CD8+
T cells play a vital role. Nonetheless, the characterization of the specificity and TCR …

Cross-reactive humoral and CD4+ T cell responses to Mu and Gamma SARS-CoV-2 variants in a Colombian population

F Martel, J Cuervo-Rojas, J Ángel, B Ariza… - Frontiers in …, 2023 - frontiersin.org
The SARS CoV-2 antibody and CD4+ T cell responses induced by natural infection and/or
vaccination decline over time and cross-recognize other viral variants at different levels …