This review summarizes the mechanisms of the initiator protein DnaA in replication initiation
and its regulation in Escherichia coli. The chromosomal origin (oriC) DNA is unwound by the …

More than 50 years have passed since the presentation of the Replicon Model which states
that a positively acting initiator interacts with a specific site on a circular chromosome …

Understanding how antibiotics impact bacterial metabolism may provide insight into their
mechanisms of action and could lead to enhanced therapeutic methodologies. Here, we …

Bisphenol A (BPA), one of the most abundant endocrine-disrupting compounds, is frequently
detected in diverse aquatic environments, which imposes a substantial burden on the …

Escherichia coli is a model organism that has been exploited to reveal key details of
hydrogen peroxide stress: the biomolecules that H 2 O 2 most rapidly damages and the …

The bactericidal effects of antibiotics are undoubtedly triggered by target-specific
interactions, but there is growing evidence that an important aspect of cytotoxicity results …

Investigating a long-standing conceptual question in bacterial physiology, we examine why
DnaA, the bacterial master replication initiator protein, exists in both ATP and ADP forms …

Genomic GC content varies widely among microbes for reasons unknown. While mutation
bias partially explains this variation, prokaryotes near-universally have a higher GC content …

DNA replication, the faithful copying of genetic material, must be tightly regulated to produce
daughter cells with intact copies of the chromosome (s). This regulated replication is initiated …

Influenza viruses account for significant morbidity worldwide. Inflammatory responses,
including excessive generation of reactive oxygen and nitrogen species (RONS), mediate …