[HTML][HTML] Going below and beyond the surface: Microneedle structure, materials, drugs, fabrication, and applications for wound healing and tissue regeneration

S Lyu, Z Dong, X Xu, HP Bei, HY Yuen, CWJ Cheung… - Bioactive materials, 2023 - Elsevier
Microneedle, as a novel drug delivery system, has attracted widespread attention due to its
non-invasiveness, painless and simple administration, controllable drug delivery, and …

Ocular drug delivery: present innovations and future challenges

V Gote, S Sikder, J Sicotte, D Pal - Journal of Pharmacology and …, 2019 - ASPET
Ocular drug delivery has always been a challenge for ophthalmologists and drug-delivery
scientists due to the presence of various anatomic and physiologic barriers. Inimitable static …

Design principles of microneedles for drug delivery and sampling applications

Z Le, J Yu, YJ Quek, B Bai, X Li, Y Shou, B Myint, C Xu… - Materials Today, 2023 - Elsevier
Microneedles technology is a powerful platform to achieve efficient transdermal delivery of
bioactive molecules for local or systemic therapies attributing to their minimally invasive …

Self-implantable double-layered micro-drug-reservoirs for efficient and controlled ocular drug delivery

A Than, C Liu, H Chang, PK Duong… - Nature …, 2018 - nature.com
Eye diseases and injuries impose a significant clinical problem worldwide. Safe and
effective ocular drug delivery is, however, challenging due to the presence of ocular barriers …

Recent advances of controlled drug delivery using microfluidic platforms

ST Sanjay, W Zhou, M Dou, H Tavakoli, L Ma… - Advanced drug delivery …, 2018 - Elsevier
Conventional systematically-administered drugs distribute evenly throughout the body, get
degraded and excreted rapidly while crossing many biological barriers, leaving minimum …

A facile low-dose photosensitizer-incorporated dissolving microneedles-based composite system for eliciting antitumor immunity and the abscopal effect

Q Bian, L Huang, Y Xu, R Wang, Y Gu, A Yuan, X Ma… - Acs Nano, 2021 - ACS Publications
Nanomedicine-based photodynamic therapy (PDT) for melanoma treatment has attracted
great attention. However, the complex design of polymer nanoparticles and high doses of …

Strategies to develop polymeric microneedles for controlled drug release

BZ Chen, YT He, ZQ Zhao, YH Feng, L Liang… - Advanced Drug Delivery …, 2023 - Elsevier
The remarkable appeal of microneedle controlled-release systems has captivated both the
academic community and pharmaceutical industry due to their great potential for achieving …

A rapid corneal healing microneedle for efficient ocular drug delivery

H Shi, J Zhou, Y Wang, Y Zhu, D Lin, L Lei, S Vakal… - Small, 2022 - Wiley Online Library
Fungal keratitis (FK) remains a serious clinical problem worldwide, so the ultimate goal of
the treatment is to develop a minimally invasive, safe, and effective method for ocular drug …

[HTML][HTML] Intravitreal hydrogels for sustained release of therapeutic proteins

BC Ilochonwu, A Urtti, WE Hennink… - Journal of Controlled …, 2020 - Elsevier
This review highlights how hydrogel formulations can improve intravitreal protein delivery to
the posterior segment of the eye in order to increase therapeutic outcome and patient …

Ocular delivery of proteins and peptides: Challenges and novel formulation approaches

A Mandal, D Pal, V Agrahari, HM Trinh… - Advanced drug delivery …, 2018 - Elsevier
The impact of proteins and peptides on the treatment of various conditions including ocular
diseases over the past few decades has been advanced by substantial breakthroughs in …