Dimerization is a promising strategy to develop novel drug candidates that could extend the
biological spectrum, enhance the activity, overcome drug resistance, as well as improve …

Tuberculosis is a life‐threatening chronic infectious disease, which primarily affects the
lungs but can spread to other vital organs. The re‐emergence and wide spread of new …

The multistep translational science behind new drugs comprehends the entire process
through laboratory, clinical, and community observations turned into health interventions …

Polymethylene-linked isatin dimers 1a-g and 3-indolyl-3-hydroxy-2-oxindole dimers 2a-g
were synthesized and are reported here as selective butyrylcholinesterase (BChE) …

In this study, we outline the synthesis of isatin–ferrocenyl chalcone and 1 H-1, 2, 3-triazole-
tethered isatin–ferrocene conjugates along with their antimicrobial evaluation against the …

A series of novel homonuclear and heteronuclear bis-isatin derivatives tethered through
ethylene were designed, synthesized and evaluated for their in vitro anti-mycobacterial …

Molecular hybridization has a wide application in medicinal chemistry to obtain new
biologically active compounds. New isatin-indole molecular hybrids 5a–n have been …

Alkylation of isatin with 1, ω-dihaloalkanes afforded bis (heterocycles) connected by an
oligomethylene linker. The reaction of the resulting bis (isatins) with Girard's T and Girard's P …

We report herein the design, synthesis, and in vitro anti‐tumor activities of a series of 1, 2, 3‐
triazole‐tetraethylene glycol tethered heteronuclear bis‐Schiff base derivatives of isatin. Our …

A series of bis-isatin conjugates with lysine linker were synthesized with the aim of probing
their antiproliferative potential. All the newly synthesized derivatives (0–100 μM) were first …